Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.45 |
| ▸ | BLM | P54132 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2804427 | 0.82 | CYP2D6 (0.45) | MEN1KMT2ACYP2D6CYP2C19LMNA | |
| SCHEMBL20835887 | 0.81 | CYP2C19 (0.50) | MEN1KMT2ACYP2D6CYP2C19LMNA | |
| SCHEMBL9337742 | 0.79 | MAPT (0.51) | MEN1KMT2ACYP2D6CYP2C19CYP1A2 | |
| SCHEMBL8668280 | 0.78 | CYP2C19 (0.42) | MEN1KMT2ACYP2D6CYP2C19LMNA | |
| SCHEMBL8666859 | 0.77 | CYP2D6 (0.39) | MEN1KMT2ACYP2D6CYP2C19LMNA | |
| SCHEMBL8954371 | 0.77 | CYP2D6 (0.39) | MEN1KMT2ACYP2D6CYP2C19LMNA | |
| SCHEMBL8670246 | 0.76 | CYP2C19 (0.41) | MEN1KMT2ACYP2D6CYP2C19LMNA | |
| SCHEMBL7433127 | 0.74 | POLB (0.45) | MEN1KMT2ACYP2D6CYP2C19LMNA | |
| SCHEMBL7433122 | 0.74 | POLB (0.45) | MEN1KMT2ACYP2D6CYP2C19LMNA | |
| SCHEMBL8669917 | 0.74 | MMP3 (0.39) | MEN1KMT2ACYP2D6CYP2C19LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4977260-A | Intermediates for preparing mono-, bi- and tricyclic amino acids | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-12-11 | — | — | US | disclosed |
| US-4849524-A | Process of preparing proline derivatives | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-07-18 | — | — | US | disclosed |
| US-4691022-A | Process for the preparation of monocyclic, bicyclic and tricyclic aminoacids | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-09-01 | — | — | US | disclosed |
| EP-0132580-A1 | Process for the preparation of mono, bi and tricyclic aminoacids | HOECHST AKTIENGESELLSCHAFT (DE) | 1985-02-13 | — | — | EP | disclosed |