Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 4/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | BLM | P54132 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.36 |
| ▸ | CTSC | P53634 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8954371 | 1.00 | CYP2D6 (0.39) | CYP2D6CYP2C19LMNABLMMEN1 | |
| SCHEMBL10469586 | 0.77 | MEN1 (0.58) | CYP2D6CYP2C19LMNABLMMEN1 | |
| SCHEMBL2804427 | 0.77 | CYP2D6 (0.45) | CYP2D6CYP2C19LMNABLMMEN1 | |
| SCHEMBL20835887 | 0.76 | CYP2C19 (0.50) | CYP2D6CYP2C19LMNABLMMEN1 | |
| SCHEMBL8954784 | 0.76 | MEN1 (0.40) | CYP2D6CYP2C19LMNABLMMEN1 | |
| SCHEMBL8668280 | 0.73 | CYP2C19 (0.42) | CYP2D6CYP2C19LMNABLMMEN1 | |
| SCHEMBL8669917 | 0.73 | MMP3 (0.39) | CYP2D6CYP2C19LMNABLMMEN1 | |
| SCHEMBL8670246 | 0.71 | CYP2C19 (0.41) | CYP2D6CYP2C19LMNABLMMEN1 | |
| SCHEMBL7433127 | 0.70 | POLB (0.45) | CYP2D6CYP2C19LMNAMEN1KMT2A | |
| SCHEMBL7433122 | 0.70 | POLB (0.45) | CYP2D6CYP2C19LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5707991-A | TREATMENT OF NERVOUS SYSTEM DISORDERS, PARKINSON'S DISEASE | RHONE-POULENC RORER S.A. (FR) | 1998-01-13 | — | — | US | disclosed |
| US-5525735-A | SYNTHETIC COMPOUND LIBRARY COMPRISING PLURALITY OF DIFFERENT PYRROLIDINE COMPOUNDS, EACH COVALENTLY LINKED TO SOLID SUPPORT | AFFYMAX TECHNOLOGIES NV (AN) | 1996-06-11 | — | — | US | disclosed |
| WO-1995035278-A1 | METHODS FOR SYNTHESIZING DIVERSE COLLECTIONS OF PYRROLIDINE COMPOUNDS | AFFYMAX TECHNOLOGIES N.V. (AN) | 1995-12-28 | — | — | WO | disclosed |