Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.39 |
| ▸ | MC4R | P32245 | 1/20 | 0.39 |
| ▸ | CTSD | P07339 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
| ▸ | HTR2B | P41595 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.34 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.33 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2061940 | 0.88 | CHRNB4 (0.50) | CHRNB4CHRNA3CHRNB2CHRNA4HTR2A | |
| Oxalic Acid SCHEMBL10680296 | 0.80 | CHRNB2 (0.46) | CHRNB2CHRNA4SLC6A4HTR2AHTR2C | |
| Oxalic Acid SCHEMBL10471042 | 0.79 | DRD1 (0.33) | CHRNB2CHRNA4HTR2CALDH1A1TDP1 | |
| SCHEMBL9660310 | 0.73 | TSHR (0.52) | SLC6A4SLC6A3TSHR | |
| Oxalic Acid SCHEMBL4623619 | 0.70 | SLC6A3 (0.44) | SLC6A3 | |
| Oxalic Acid SCHEMBL10472959 | 0.69 | S1PR5 (0.51) | ALDH1A1 | |
| Oxalic Acid SCHEMBL10678210 | 0.68 | KDM4E (0.44) | ALDH1A1TDP1 | |
| Oxalic Acid SCHEMBL10674199 | 0.67 | LMNA (0.42) | ALDH1A1TDP1 | |
| SCHEMBL1036653 | 0.67 | CHRNB2 (0.45) | CHRNB4CHRNA3CHRNB2CHRNA4HTR2A | |
| SCHEMBL29598614 | 0.67 | SLC6A2 (0.44) | CHRNB4CHRNA3SLC6A4SLC6A3HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4910198-A | Antiarrhythmia agent | ORTHO PHARMACEUTICAL CORPORATION (US) | 1990-03-20 | — | — | US | claimed |
| US-4761413-A | CYTOPROTECTION, ANTISECRETORY AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1988-08-02 | — | — | US | claimed |
| US-4910198-A | Antiarrhythmia agent | ORTHO PHARMACEUTICAL CORPORATION (US) | 1990-03-20 | — | — | US | disclosed |
| US-4855426-A | Process of preparing 1,5-epoxy-2,3,4,5-tetrahydro-1H-3-benzazepins | ORTHO PHARMACEUTICAL CORPORATION (US) | 1989-08-08 | — | — | US | disclosed |
| US-4761413-A | CYTOPROTECTION, ANTISECRETORY AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1988-08-02 | — | — | US | disclosed |