Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 1/20 | 0.37 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16692609 | 0.98 | ALDH1A1 (0.37) | ALDH1A1KDM4EADRB2SLC6A2SLC6A4 | |
| SCHEMBL8262524 | 0.92 | — | — | |
| SCHEMBL25075482 | 0.84 | MAPK1 (0.39) | ALDH1A1KDM4EADRB2HTR1BNR2E1 | |
| SCHEMBL28765742 | 0.82 | KDM4E (0.39) | ALDH1A1KDM4EADRB2HTR1BNR2E1 | |
| SCHEMBL178420 | 0.81 | — | — | |
| SCHEMBL2600364 | 0.81 | HRH4 (0.43) | ALDH1A1KDM4EADRB2HTR1BNR2E1 | |
| SCHEMBL5115915 | 0.79 | SLC6A4 (0.34) | ALDH1A1KDM4ESLC6A2SLC6A4SLC6A3 | |
| SCHEMBL15182519 | 0.79 | ADRB2 (0.39) | ALDH1A1KDM4EADRB2HTR1BNR2E1 | |
| Hydrochloric Acid SCHEMBL9731497 | 0.79 | — | — | |
| SCHEMBL24477365 | 0.78 | ALDH1A1 (0.44) | ALDH1A1KDM4EADRB2HTR1BNR2E1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10040771-B2 | Method for preparing prostacyclin receptor agonist 4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]-1-butanol | Seasons Biotechnology (Taizhou) Co., Ltd. (CN) | 2018-08-07 | — | — | US | disclosed |
| US-20180029998-A1 | METHOD FOR PREPARING PROSTACYCLIN RECEPTOR AGONIST | Seasons Biotechnology (Taizhou) Co., Ltd. (CN) | 2018-02-01 | — | — | US | disclosed |
| US-20120059162-A1 | FUSED IMIDAZOLE DERIVATIVE HAVING TTK INHIBITORY ACTION | ONCOTHERAPY SCIENCE, INC. (JP) | 2012-03-08 | — | — | US | disclosed |
| EP-2103619-A1 | IMIDAZOTHIAZOLE DERIVATIVES | Daiichi Sankyo Company, Limited (JP) | 2009-09-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10040771-B2 | Method for preparing prostacyclin receptor agonist 4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]-1-butanol | PTGIR, TBXA2R, PTGIS | ALDH1A1 1155/4885KDM4E 3409/4885ADRB2 13/4885 |
| US-20120059162-A1 | FUSED IMIDAZOLE DERIVATIVE HAVING TTK INHIBITORY ACTION | NR0B1, GRK7, NR5A2 | ALDH1A1 3128/4885KDM4E 2800/4885ADRB2 223/4885 |
| US-20180029998-A1 | METHOD FOR PREPARING PROSTACYCLIN RECEPTOR AGONIST | PTGIR, TBXA2R, PTGIS | ALDH1A1 2211/4885KDM4E 3408/4885ADRB2 30/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.