Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.67 |
| ▸ | RAB9A | P51151 | 4/20 | 0.67 |
| ▸ | NPC1 | O15118 | 3/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | NAAA | Q02083 | 2/20 | 0.57 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | MLYCD | O95822 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13577935 | 0.95 | HPGD (0.68) | HPGDSMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL7538215 | 0.94 | L3MBTL1 (0.69) | HPGDSMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL17132595 | 0.90 | HPGD (0.65) | HPGDSMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL28326194 | 0.88 | L3MBTL1 (0.73) | SMN1; SMN2RAB9ANPC1L3MBTL1NAAA | |
| SCHEMBL12920005 | 0.87 | HPGD (0.75) | HPGDSMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL24904337 | 0.85 | HPGD (0.68) | HPGDSMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL18232447 | 0.85 | HPGD (0.68) | HPGDSMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL18232444 | 0.85 | HPGD (0.68) | HPGDSMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL14020489 | 0.84 | ALDH1A1 (0.78) | HPGDSMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL16789651 | 0.84 | HPGD (0.67) | HPGDSMN1; SMN2RAB9ANPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120059162-A1 | FUSED IMIDAZOLE DERIVATIVE HAVING TTK INHIBITORY ACTION | ONCOTHERAPY SCIENCE, INC. (JP) | 2012-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120059162-A1 | FUSED IMIDAZOLE DERIVATIVE HAVING TTK INHIBITORY ACTION | NR0B1, GRK7, NR5A2 | HPGD 4110/4885SMN1; SMN2 4581/4885RAB9A 3030/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.