Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN2 | P17706 | 6/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 6/20 | 0.48 |
| ▸ | PTPN5 | P54829 | 4/20 | 0.48 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.48 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10480337 | 0.81 | PTPN2 (0.48) | PTPN2PTPN1PTPN5MAPTLMNA | |
| SCHEMBL10480340 | 0.72 | ALDH1A1 (0.48) | PTPN2PTPN1LMNAGAAALOX15 | |
| SCHEMBL2123396 | 0.72 | MAPT (0.50) | MAPTLMNAGAAALOX15TDP1 | |
| SCHEMBL86097 | 0.71 | MAPT (0.48) | MAPTLMNAGAAALDH1A1KDM4E | |
| SCHEMBL2147325 | 0.71 | MAPT (0.48) | MAPTLMNAGAAALOX15TDP1 | |
| SCHEMBL11763172 | 0.70 | LMNA (0.44) | PTPN2PTPN1MAPTLMNAGAA | |
| SCHEMBL23342452 | 0.69 | MAPT (0.46) | MAPTLMNAGAAALDH1A1KDM4E | |
| SCHEMBL8069919 | 0.69 | MAPT (0.46) | MAPTLMNAGAAALDH1A1KDM4E | |
| SCHEMBL12396620 | 0.69 | MAPT (0.46) | MAPTLMNAGAAALDH1A1KDM4E | |
| SCHEMBL10902610 | 0.69 | MAPT (0.46) | MAPTLMNAGAAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4822809-A | ENZYME INHIBITORS | ABBOTT LABORATORIES (US) | 1989-04-18 | — | — | US | disclosed |