Sugi Predict

Sugi Predict / Compounds / SCHEMBL10488677

SCHEMBL10488677

SCHEMBL10488677

Cc1cccc(C)c1NC(=S)NN

nearest known ligand 0.77

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GAA P10253 5/20 0.77
▸ LMNA P02545 2/20 0.56
▸ POLB P06746 1/20 0.54
▸ ATM Q13315 1/20 0.54
▸ ALOX12 P18054 3/20 0.53
▸ MAPT P10636 3/20 0.51
▸ ALDH1A1 P00352 2/20 0.51
▸ SMN1; SMN2 Q16637 1/20 0.51
▸ MEN1 O00255 1/20 0.47
▸ KMT2A Q03164 1/20 0.47
▸ L3MBTL1 Q9Y468 1/20 0.47
▸ GRIN2D O15399 1/20 0.47
▸ GRIN3B O60391 1/20 0.47
▸ GRIN1 Q05586 1/20 0.47
▸ GRIN2A Q12879 1/20 0.47
▸ GRIN2B Q13224 1/20 0.47
▸ GRIN2C Q14957 1/20 0.47
▸ GRIN3A Q8TCU5 1/20 0.47
▸ SIGMAR1 Q99720 1/20 0.47
▸ RECQL P46063 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Alcohol SCHEMBL16401346 0.93 GAA (0.68) GAALMNAPOLBATMALOX12
SCHEMBL8513843 0.87 GAA (1.00) GAALMNAPOLBATMMAPT
SCHEMBL15484311 0.87 LMNA (0.69) GAALMNAPOLBATMALOX12
SCHEMBL16401841 0.84 ALDH1A1 (0.63) GAALMNAPOLBALOX12MAPT
SCHEMBL5450399 0.81 LMNA (0.58) GAALMNAPOLBATMALOX12
SCHEMBL5222474 0.78 GRIN2D (0.55) GAALMNAPOLBATMALOX12
SCHEMBL25206832 0.78 LMNA (0.59) GAALMNAPOLBATMALOX12
SCHEMBL20672953 0.78 POLB (0.62) GAALMNAPOLBATMALOX12
SCHEMBL15897567 0.78 LMNA (0.54) GAALMNAPOLBATMALOX12
SCHEMBL5434789 0.78 MAPT (0.61) GAALMNAALOX12MAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115449136-B Accelerator composition of rubber nanocomposite as well as preparation method and application thereof 浙江大学 2024-02-27 — — CN claimed
CN-115449136-A Accelerator composition of rubber nanocomposite and preparation method and application thereof 浙江大学 2022-12-09 — — CN claimed
CN-110506038-B Pesticidal compounds 巴斯夫欧洲公司 2023-11-24 — — CN disclosed
EP-3601231-B1 PESTICIDAL COMPOUNDS BASF SE (DE) 2023-05-10 — — EP disclosed
CN-115449136-A Accelerator composition of rubber nanocomposite and preparation method and application thereof 浙江大学 2022-12-09 — — CN disclosed
US-11160280-B2 Pesticial compounds BASF SE (DE) 2021-11-02 — — US disclosed
CN-107207450-B Pesticidally active semicarbazone and thiosemicarbazone derivatives 先正达参股股份有限公司 2021-07-06 — — CN disclosed
EP-3715340-A1 PESTICIDALLY ACTIVE SEMI-CARBAZONES AND THIOSEMICARBAZONES DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2020-09-30 — — EP disclosed
EP-3715340-A1 PESTICIDALLY ACTIVE SEMI-CARBAZONES AND THIOSEMICARBAZONES DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2020-09-30 — — EP disclosed
US-10730848-B2 Protective molecules against anthrax toxin THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2020-08-04 — — US disclosed
US-10721933-B2 Pesticidally active semi-carbazones and thiosemicarbazones derivatives SYNGENTA PARTICIPATIONS AG (CH) 2020-07-28 — — US disclosed
EP-3022185-A1 PESTICIDE COMPOUNDS BASF SE (DE) 2016-05-25 — — EP disclosed
US-20160016930-A1 PROTECTIVE MOLECULES AGAINST ANTHRAX TOXIN NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2016-01-21 — — US disclosed
US-20160016930-A1 PROTECTIVE MOLECULES AGAINST ANTHRAX TOXIN NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2016-01-21 — — US disclosed
WO-2015007682-A1 PESTICIDE COMPOUNDS BASF SE (DE) 2015-01-22 — — WO disclosed
WO-2014113607-A1 PROTECTIVE MOLECULES AGAINST ANTHRAX TOXIN THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2014-07-24 — — WO disclosed
CN-102532126-B 2-substituted-4-chloro-5-[5-subtsituted amino-2-(1,3,4-thiadiazole)-sulfydryl]-3(2H)- pyridazinone derivatives, and preparation method and application thereof UNIV GUIZHOU 2014-06-18 — — CN disclosed
US-4871737-A 3-Amino-5-methyl-1H-pyrazole-4-carboxylic acids and esters thereof as anticonvulsants muscle relaxants and anxiolytics A. H. ROBINS COMPANY, INCORPORATED (US) 1989-10-03 — — US disclosed
EP-0315433-A2 3-amino-5-methyl-1H-pyrazole-4-carboxylic acids and esters thereof as anticonvulsants, muscle relaxants and anxiolytics A.H. ROBINS COMPANY, INCORPORATED (US) 1989-05-10 — — EP disclosed
US-4826866-A 3-amino-5-methyl-1H-pyrazole-4-carboxylic acids and esters thereof as anticonvulsants, muscle relaxants and anxiolytics A. H. ROBINS COMPANY, INCORPORATED (US) 1989-05-02 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11160280-B2 Pesticial compounds PNMT, DDT, NIT2 GAA 3187/4885LMNA 2031/4885POLB 2894/4885
US-20160016930-A1 PROTECTIVE MOLECULES AGAINST ANTHRAX TOXIN ANTXR2, TSG101, ANXA1 GAA 1322/4885LMNA 368/4885POLB 1959/4885
US-10721933-B2 Pesticidally active semi-carbazones and thiosemicarbazones derivatives DDT, ACHE, CAT GAA 2451/4885LMNA 4840/4885POLB 4223/4885
US-10730848-B2 Protective molecules against anthrax toxin ANTXR2, TSG101, ANXA1 GAA 1322/4885LMNA 368/4885POLB 1959/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.