SCHEMBL10490641

SCHEMBL10490641

CCC(Cl)c1cccc(C=O)c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.41
UNG P13051 1/20 0.38
HDAC4 P56524 1/20 0.37
HDAC2 Q92769 1/20 0.37
HDAC8 Q9BY41 1/20 0.37
MAOA P21397 3/20 0.36
MAOB P27338 3/20 0.36
NPC1 O15118 1/20 0.36
RAB9A P51151 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
CYP2A6 P11509 1/20 0.35
PGK1 P00558 1/20 0.35
PGK2 P07205 1/20 0.35
ALDH1A3 P47895 2/20 0.35
ALDH3A1 P30838 1/20 0.35
TYR P14679 1/20 0.34
SRC P12931 1/20 0.34
DRD2 P14416 1/20 0.34
DRD1 P21728 1/20 0.34
DRD4 P21917 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4099672 0.80 HDAC4 (0.53) ALDH1A1UNGHDAC4HDAC2HDAC8
SCHEMBL4950119 0.79 ALDH1A1 (0.48) ALDH1A1UNGMAOAMAOBNPC1
SCHEMBL4808239 0.79 ALDH1A1 (0.48) ALDH1A1UNGMAOAMAOBRAB9A
SCHEMBL14231960 0.79 ALDH1A1 (0.41) ALDH1A1UNGHDAC4HDAC2HDAC8
SCHEMBL663468 0.76 MAOA (0.41) ALDH1A1UNGMAOAMAOBNPC1
SCHEMBL30291836 0.75 TYR (0.56) ALDH1A1UNGHDAC4HDAC2HDAC8
SCHEMBL727874 0.75 TYR (0.56) ALDH1A1UNGHDAC4HDAC2HDAC8
SCHEMBL13779285 0.75 UNG (0.39) ALDH1A1UNGMAOAMAOBNPC1
SCHEMBL2048449 0.74 PTGS2 (0.44) ALDH1A1UNGMAOAMAOBNPC1
SCHEMBL9772613 0.73 ACHE (0.44) ALDH1A1HDAC4HDAC2HDAC8TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4868241-A POLYVINYL ALCOHOL MODIFIED WITH BENZOIC ACID DERIVATIVE AMERICAN CYANAMID COMPANY (US) 1989-09-19 US disclosed