Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 1/20 | 0.46 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | HTR7 | P34969 | 2/20 | 0.40 |
| ▸ | HTR1D | P28221 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR5A | P47898 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2773853 | 0.85 | MCHR1 (0.53) | MCHR1IRAK4ALDH1A1HTR1AHTR7 | |
| SCHEMBL11916618 | 0.79 | SLC6A2 (0.43) | MCHR1IRAK4ALDH1A1GAAHTR1A | |
| SCHEMBL2841640 | 0.79 | MCHR1 (0.49) | MCHR1IRAK4ALDH1A1GAAHTR1A | |
| SCHEMBL17070600 | 0.79 | ALDH1A1 (0.53) | IRAK4ALDH1A1GAAALOX5APFEN1 | |
| SCHEMBL104729 | 0.79 | ALDH1A1 (0.53) | IRAK4ALDH1A1GAAALOX5APFEN1 | |
| SCHEMBL16606250 | 0.78 | MCHR1 (0.40) | MCHR1IRAK4ALDH1A1GAAALOX5AP | |
| SCHEMBL13263183 | 0.78 | KCNN4 (0.41) | MCHR1IRAK4ALDH1A1GAAALOX5AP | |
| SCHEMBL5409325 | 0.78 | MCHR1 (0.47) | MCHR1IRAK4ALDH1A1HTR1AHTR7 | |
| SCHEMBL108534 | 0.77 | TDP1 (0.48) | MCHR1ALDH1A1GAACA1CA2 | |
| SCHEMBL17887314 | 0.76 | MCHR1 (0.46) | MCHR1IRAK4ALDH1A1HTR1AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3237385-B1 | MUTANT IDH1 INHIBITORS USEFUL FOR TREATING CANCER | US HEALTH (US) | 2021-11-24 | — | — | EP | disclosed |
| US-10703746-B2 | Mutant IDH1 inhibitors useful for treating cancer | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2020-07-07 | — | — | US | disclosed |
| US-20190071434-A1 | MUTANT IDH1 INHIBITORS USEFUL FOR TREATING CANCER | THE USA AS REPRESENTED BY THE SEC DEP OF HEALTH AND HUMAN SERVICES (US) | 2019-03-07 | — | — | US | disclosed |
| EP-3129358-A1 | DIAMINOTRIAZINE DERIVATIVES AS HERBICIDES | BASF SE (DE) | 2017-02-15 | — | — | EP | disclosed |
| US-20170029383-A1 | Diaminotriazine Derivatives as Herbicides | BASF SE (DE) | 2017-02-02 | — | — | US | disclosed |
| CN-106164058-A | Diaminourea pyrrolotriazine derivatives as herbicide | 巴斯夫欧洲公司 | 2016-11-23 | — | — | CN | disclosed |
| WO-2016106331-A1 | MUTANT IDH1 INHIBITORS USEFUL FOR TREATING CANCER | THE UNITED STATES OF AMERICA (US) | 2016-06-30 | — | — | WO | disclosed |
| WO-2015155271-A1 | DIAMINOTRIAZINE DERIVATIVES AS HERBICIDES | BASF SE (DE) | 2015-10-15 | — | — | WO | disclosed |
| US-20120059162-A1 | FUSED IMIDAZOLE DERIVATIVE HAVING TTK INHIBITORY ACTION | ONCOTHERAPY SCIENCE, INC. (JP) | 2012-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120059162-A1 | FUSED IMIDAZOLE DERIVATIVE HAVING TTK INHIBITORY ACTION | NR0B1, GRK7, NR5A2 | MCHR1 1652/4885IRAK4 1082/4885ALDH1A1 3128/4885 |
| US-20170029383-A1 | Diaminotriazine Derivatives as Herbicides | DDT, CBR3, HDHD5 | MCHR1 2093/4885IRAK4 4405/4885ALDH1A1 348/4885 |
| US-20190071434-A1 | MUTANT IDH1 INHIBITORS USEFUL FOR TREATING CANCER | IDH1, IDH3B, IDH3A | MCHR1 4586/4885IRAK4 3380/4885ALDH1A1 417/4885 |
| US-10703746-B2 | Mutant IDH1 inhibitors useful for treating cancer | IDH1, IDH3B, IDH3A | MCHR1 4586/4885IRAK4 3380/4885ALDH1A1 417/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.