SCHEMBL10498367

SCHEMBL10498367

CC(=O)c1cc(I)cc(I)c1

nearest known ligand 0.52

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CA5A P35218 1/20 0.52
LMNA P02545 2/20 0.43
TTR P02766 1/20 0.39
MAPT P10636 3/20 0.37
HPGD P15428 2/20 0.37
RAB9A P51151 2/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
KMT2A Q03164 1/20 0.37
NPC1 O15118 1/20 0.37
HSD17B1 P14061 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
CYP2A6 P11509 1/20 0.35
TPMT P51580 2/20 0.35
PKM P14618 1/20 0.34
CA1 P00915 1/20 0.33
CA2 P00918 1/20 0.33
PRKCI P41743 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13307545 0.94 CA5A (0.52) CA5ALMNATTRMAPTHPGD
SCHEMBL200586 0.84 CA5A (0.43) CA5ALMNATTRMAPTHPGD
SCHEMBL26473858 0.84 TPMT (0.43) CA5ALMNATTRMAPTHPGD
SCHEMBL12993691 0.80 CA12 (0.50) CA5ALMNAMAPTHPGDL3MBTL1
SCHEMBL26473968 0.79 CES2 (0.50) CA5AMAPTKMT2A
SCHEMBL669554 0.78 CA5A (0.67) CA5ALMNAMAPTHPGDRAB9A
SCHEMBL7142694 0.77 CA2 (0.43) CA5ASMN1; SMN2CA1CA2
SCHEMBL16951140 0.77 TTR (0.43) TTR
SCHEMBL13624841 0.76 CA5A (0.56) CA5ALMNATTRHPGDKMT2A
SCHEMBL14264012 0.76 TPMT (0.61) CA5ALMNAMAPTHPGDRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114956933-A Marker containing isotope oxygen atom and preparation method and application thereof 清华大学 2022-08-30 CN disclosed
EP-0328669-A1 CHALCONE DERIVATIVE COMPOUNDS NIPPON OIL AND FATS COMPANY, LIMITED (JP) 1989-08-23 EP disclosed