SCHEMBL10499080

SCHEMBL10499080

O=S(=O)(c1cc(Cl)c(Cl)c(Cl)c1)C(F)(F)F

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.44
MEN1 O00255 1/20 0.44
KMT2A Q03164 1/20 0.44
EPAS1 Q99814 8/20 0.43
CA2 P00918 4/20 0.41
CA1 P00915 3/20 0.41
CA9 Q16790 3/20 0.41
LMNA P02545 2/20 0.41
CA12 O43570 1/20 0.41
CYP2C9 P11712 1/20 0.41
CA4 P22748 1/20 0.41
CA6 P23280 1/20 0.41
CA5A P35218 1/20 0.41
CA7 P43166 1/20 0.41
CA13 Q8N1Q1 1/20 0.41
CA14 Q9ULX7 1/20 0.41
CA5B Q9Y2D0 1/20 0.41
MAPK1 P28482 1/20 0.36
HTT P42858 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11062896 0.83 CA2 (0.57) ALDH1A1MEN1KMT2AEPAS1CA2
SCHEMBL1334378 0.80 ALDH1A1 (0.54) ALDH1A1MEN1KMT2AEPAS1CA2
SCHEMBL7750645 0.78 ALDH1A1 (0.55) ALDH1A1MEN1KMT2AEPAS1CA2
SCHEMBL10497555 0.78 MEN1 (0.42) ALDH1A1MEN1KMT2AEPAS1CA2
SCHEMBL699257 0.76 ALDH1A1 (0.42) ALDH1A1MEN1KMT2AEPAS1LMNA
SCHEMBL16555813 0.75 EPAS1 (0.56) ALDH1A1MEN1KMT2AEPAS1
SCHEMBL11844072 0.74 CA1 (0.38) ALDH1A1CA2CA1CA9LMNA
SCHEMBL1881348 0.74 ALDH1A1 (0.70) ALDH1A1MEN1KMT2AEPAS1CA2
SCHEMBL21728893 0.74 MEN1 (0.53) ALDH1A1MEN1KMT2AEPAS1LMNA
SCHEMBL11412901 0.74 MEN1 (0.53) ALDH1A1MEN1KMT2AEPAS1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0187285-B1 PROCESS FOR THE PREPARATION OF SUBSTITUTED PHENYL HYDRAZINES BAYER AG (DE) 1989-09-06 EP disclosed
EP-0187285-A2 Process for the preparation of substituted phenyl hydrazines BAYER AG (DE) 1986-07-16 EP disclosed