Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 4/20 | 0.47 |
| ▸ | MPI | P34949 | 1/20 | 0.46 |
| ▸ | PHOSPHO1 | Q8TCT1 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10501489 | 0.86 | METAP2 (0.64) | METAP2MPIPHOSPHO1 | |
| SCHEMBL10501994 | 0.84 | POLB (0.52) | METAP2POLBMAPTALDH1A1NPC1 | |
| SCHEMBL10501763 | 0.84 | ALDH1A1 (0.44) | METAP2MPIPHOSPHO1TSHRCYP3A4 | |
| SCHEMBL10501435 | 0.81 | SMN1; SMN2 (0.45) | METAP2TSHRMAPTLMNAALDH1A1 | |
| SCHEMBL10502143 | 0.80 | METAP2 (0.45) | METAP2MPIPHOSPHO1TSHRCYP3A4 | |
| SCHEMBL10501645 | 0.80 | MPI (0.54) | METAP2MPIPHOSPHO1MAPTALDH1A1 | |
| SCHEMBL10501678 | 0.78 | METAP2 (0.49) | METAP2MPIPHOSPHO1 | |
| SCHEMBL10501600 | 0.78 | METAP2 (0.71) | METAP2MPIPHOSPHO1 | |
| SCHEMBL10501265 | 0.78 | MPI (0.49) | METAP2MPIPHOSPHO1TSHRCYP3A4 | |
| SCHEMBL10502376 | 0.77 | MPI (0.69) | METAP2MPIPHOSPHO1CYP3A4POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0154851-B1 | BENZISOSELENAZOLETHIONES,PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL PRODUCTS CONTAINING THESE COMPOUNDS | A. Nattermann & Cie. GmbH (DE) | 1989-08-02 | — | — | EP | disclosed |
| US-4711961-A | Benzisoselenazolethiones and process for the treatment of various diseases in humans | A. NATTERMANN & CIE GMBH (DE) | 1987-12-08 | — | — | US | disclosed |
| EP-0154851-A1 | Benzisoselenazolethiones,process for their preparation and pharmaceutical products containing these compounds | A. Nattermann & Cie. GmbH (DE) | 1985-09-18 | — | — | EP | disclosed |