Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | METAP2 | P50579 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10502075 | 0.87 | METAP2 (0.68) | POLBMETAP2ALDH1A1MAPK1 | |
| SCHEMBL10501110 | 0.84 | METAP2 (0.47) | POLBMETAP2ALDH1A1MAPK1MAPT | |
| SCHEMBL10501763 | 0.81 | ALDH1A1 (0.44) | POLBMETAP2ALDH1A1MAPTHTT | |
| SCHEMBL10501743 | 0.80 | METAP2 (0.54) | METAP2ALDH1A1MAPTHTT | |
| SCHEMBL10500974 | 0.78 | METAP2 (0.54) | METAP2ALDH1A1MAPTHTT | |
| SCHEMBL10501435 | 0.76 | SMN1; SMN2 (0.45) | METAP2ALDH1A1MAPK1MAPTSMN1; SMN2 | |
| SCHEMBL10502143 | 0.75 | METAP2 (0.45) | METAP2ALDH1A1MAPK1MAPTSMN1; SMN2 | |
| SCHEMBL10501336 | 0.73 | METAP2 (0.50) | POLBMETAP2ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL10502310 | 0.73 | METAP2 (0.52) | POLBMETAP2ALDH1A1MAPTHTT | |
| SCHEMBL10502111 | 0.73 | METAP2 (0.68) | POLBMETAP2ALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0154851-B1 | BENZISOSELENAZOLETHIONES,PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL PRODUCTS CONTAINING THESE COMPOUNDS | A. Nattermann & Cie. GmbH (DE) | 1989-08-02 | — | — | EP | disclosed |
| US-4711961-A | Benzisoselenazolethiones and process for the treatment of various diseases in humans | A. NATTERMANN & CIE GMBH (DE) | 1987-12-08 | — | — | US | disclosed |
| EP-0154851-A1 | Benzisoselenazolethiones,process for their preparation and pharmaceutical products containing these compounds | A. Nattermann & Cie. GmbH (DE) | 1985-09-18 | — | — | EP | disclosed |