Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | RAB9A | P51151 | 4/20 | 0.59 |
| ▸ | TSHR | P16473 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.57 |
| ▸ | CDC25A | P30304 | 1/20 | 0.57 |
| ▸ | CDC25B | P30305 | 1/20 | 0.57 |
| ▸ | PTPRC | P08575 | 2/20 | 0.57 |
| ▸ | S100A4 | P26447 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.57 |
| ▸ | APAF1 | O14727 | 1/20 | 0.57 |
| ▸ | TDP2 | O95551 | 1/20 | 0.57 |
| ▸ | NSD2 | O96028 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10503214 | 0.81 | NPC1 (0.55) | NPC1ALDH1A1RAB9ATSHRSMN1; SMN2 | |
| SCHEMBL3135129 | 0.80 | NPC1 (0.86) | NPC1ALDH1A1RAB9ATSHRSMN1; SMN2 | |
| SCHEMBL516210 | 0.80 | NPC1 (0.86) | NPC1ALDH1A1RAB9ATSHRSMN1; SMN2 | |
| SCHEMBL28005394 | 0.78 | NPC1 (0.82) | NPC1ALDH1A1RAB9ATSHRSMN1; SMN2 | |
| SCHEMBL31087632 | 0.76 | NPC1 (0.78) | NPC1ALDH1A1RAB9ATSHRSMN1; SMN2 | |
| SCHEMBL9019017 | 0.76 | NPC1 (0.78) | NPC1ALDH1A1RAB9ATSHRSMN1; SMN2 | |
| SCHEMBL10502712 | 0.76 | S100A4 (0.59) | NPC1RAB9AMAP2K7CDC25ACDC25B | |
| SCHEMBL30350052 | 0.75 | NPC1 (0.77) | NPC1ALDH1A1RAB9ATSHRSMN1; SMN2 | |
| SCHEMBL7915048 | 0.75 | PTPRC (0.82) | NPC1ALDH1A1RAB9ATSHRSMN1; SMN2 | |
| SCHEMBL5551699 | 0.75 | S100A4 (0.82) | NPC1ALDH1A1RAB9ATSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0146145-B1 | NAPHTHALENE ANTI-PSORIATIC AGENTS | SYNTEX (U.S.A.) INC. (US) | 1989-08-30 | — | — | EP | disclosed |
| US-4593120-A | Naphthalene-1,4-dicarboxylic acid group | SYNTEX (U.S.A.) INC. (US) | 1986-06-03 | — | — | US | disclosed |
| EP-0107512-B1 | 1,4-ACYLOXYNAPHTHALENE DERIVATIVES, TOPICAL COMPOSITIONS CONTAINING THEM, METHODS FOR THEIR PREPARATION, AND INTERMEDIATES THEREFOR | SYNTEX (U.S.A.) INC. (US) | 1986-02-26 | — | — | EP | disclosed |
| EP-0146145-A2 | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1985-06-26 | — | — | EP | disclosed |
| US-4466981-A | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1984-08-21 | — | — | US | disclosed |
| EP-0107512-A1 | 1,4-Acyloxynaphthalene derivatives, topical compositions containing them, methods for their preparation, and intermediates therefor | SYNTEX (U.S.A.) INC. (US) | 1984-05-02 | — | — | EP | disclosed |