Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 9/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 6/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10594457 | 0.90 | ADRB2 (0.36) | ADRB2ADRB1KMT2AKDM4EALDH1A1 | |
| SCHEMBL10595316 | 0.89 | HTR1A (0.38) | ABCB11HTR1AADRA2APTGS1SLC6A2 | |
| SCHEMBL10595607 | 0.88 | ADRB1 (0.38) | ADRB2ADRB1KMT2AMEN1KDM4E | |
| SCHEMBL10504503 | 0.87 | HTR1A (0.37) | ABCB11HTR1AADRA2APTGS1SLC6A2 | |
| SCHEMBL10503386 | 0.85 | ADRB1 (0.39) | ADRB2ADRB1KMT2AMEN1KDM4E | |
| SCHEMBL10504142 | 0.81 | ADRB1 (0.39) | ADRB2ADRB1KMT2AMEN1KDM4E | |
| SCHEMBL10504639 | 0.80 | HTR1A (0.52) | ABCB11HTR1AADRA2APTGS1SLC6A2 | |
| SCHEMBL10504381 | 0.79 | ADRB1 (0.42) | HTR1AADRB2ADRB1KDM4EALDH1A1 | |
| SCHEMBL10593255 | 0.79 | L3MBTL1 (0.40) | SLC6A2ADRB2ADRB1KMT2AMEN1 | |
| SCHEMBL10505524 | 0.79 | ADRB2 (0.38) | ADRB2ADRB1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0200915-B1 | AMINOPROPANOL DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AND MEDICINES CONTAINING THEM | Roche Diagnostics GmbH (DE) | 1989-09-27 | — | — | EP | disclosed |
| US-4863949-A | CARDIOVASCULAR DISORDER TREATMENT | BOEHRINGER MANNHEIM GMBH (DE) | 1989-09-05 | — | — | US | disclosed |
| EP-0200915-A1 | Aminopropanol derivatives, process for their preparation, their use and medicines containing them | Roche Diagnostics GmbH (DE) | 1986-11-12 | — | — | EP | disclosed |