Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 6/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 6/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10504639 | 0.90 | HTR1A (0.52) | HTR1ASLC6A2ABCB11ADRA2APTGS1 | |
| SCHEMBL10503674 | 0.89 | ABCB11 (0.38) | HTR1ASLC6A2ABCB11ADRA2APTGS1 | |
| SCHEMBL10505008 | 0.89 | ADRB3 (0.38) | CYP3A4CYP2D6ADRB1ADRB2ADRB3 | |
| SCHEMBL10504503 | 0.88 | HTR1A (0.37) | HTR1ASLC6A2ABCB11ADRA2APTGS1 | |
| SCHEMBL10595244 | 0.82 | KMT2A (0.41) | KMT2AMEN1LMNACYP3A4CYP2D6 | |
| SCHEMBL10865205 | 0.82 | ADRB1 (0.39) | KMT2AMEN1ADRB1ADRB2ADRB3 | |
| SCHEMBL10864349 | 0.79 | CYP3A4 (0.36) | HTR1AKMT2AMEN1CYP3A4CYP2D6 | |
| SCHEMBL10594457 | 0.79 | ADRB2 (0.36) | KMT2AL3MBTL1ADRB1ADRB2ADRB3 | |
| SCHEMBL10503624 | 0.79 | ADRB2 (0.52) | HTR1ASLC6A2ABCB11ADRA2APTGS1 | |
| SCHEMBL10503386 | 0.78 | ADRB1 (0.39) | KMT2AMEN1ADRB1ADRB2ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4863949-A | CARDIOVASCULAR DISORDER TREATMENT | BOEHRINGER MANNHEIM GMBH (DE) | 1989-09-05 | — | — | US | disclosed |
| EP-0200915-A1 | Aminopropanol derivatives, process for their preparation, their use and medicines containing them | Roche Diagnostics GmbH (DE) | 1986-11-12 | — | — | EP | disclosed |