Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HMGCR | P04035 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | ACACA | Q13085 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9764588 | 0.81 | TSHR (0.40) | GPR84ALDH1A1KMT2ATSHR | |
| SCHEMBL9764526 | 0.80 | GPR84 (0.33) | GPR84ALDH1A1FFAR4FFAR1KMT2A | |
| Bicarbonate SCHEMBL28611463 | 0.79 | EPHX1 (0.44) | GPR84FFAR1TSHR | |
| Bicarbonate SCHEMBL28454760 | 0.79 | EPHX1 (0.44) | GPR84FFAR1TSHR | |
| SCHEMBL2180615 | 0.78 | ALDH1A1 (0.46) | ALDH1A1MAPTTSHRHIF1AHSD17B10 | |
| SCHEMBL27587755 | 0.78 | GPR84 (0.66) | GPR84ALDH1A1FFAR4FFAR1KMT2A | |
| SCHEMBL1208925 | 0.77 | ALDH1A1 (0.55) | ALDH1A1 | |
| SCHEMBL6808670 | 0.77 | ALDH1A1 (0.55) | ALDH1A1 | |
| SCHEMBL8651989 | 0.77 | ALDH1A1 (0.55) | ALDH1A1 | |
| SCHEMBL4362453 | 0.76 | ALDH1A1 (0.43) | ALDH1A1SLC22A6MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0194610-B1 | SUBSTITUTED GLUTARIC ACID LACTONES IN THE TREATMENT OF HYPERLIPIDEMIA | G.D. Searle & Co. (US) | 1989-02-22 | — | — | EP | disclosed |
| EP-0194610-A1 | Substituted glutaric acid lactones in the treatment of hyperlipidemia | G.D. Searle & Co. (US) | 1986-09-17 | — | — | EP | disclosed |