Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.33 |
| ▸ | ACLY | P53396 | 6/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
| ▸ | ACACA | Q13085 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10778049 | 0.85 | FFAR1 (0.35) | ALDH1A1ACACBACACAFFAR1 | |
| SCHEMBL10781996 | 0.85 | FFAR1 (0.35) | ALDH1A1ACACBACACAFFAR1 | |
| SCHEMBL10777116 | 0.85 | FFAR1 (0.35) | ALDH1A1ACACBACACAFFAR1 | |
| SCHEMBL10506484 | 0.80 | GPR84 (0.53) | GPR84ALDH1A1KMT2AFFAR4ACACB | |
| SCHEMBL9764605 | 0.79 | — | — | |
| Bicarbonate SCHEMBL28611463 | 0.72 | EPHX1 (0.44) | GPR84FFAR1 | |
| Bicarbonate SCHEMBL28454760 | 0.72 | EPHX1 (0.44) | GPR84FFAR1 | |
| SCHEMBL2180615 | 0.72 | ALDH1A1 (0.46) | ALDH1A1 | |
| SCHEMBL10938912 | 0.71 | ALDH1A1 (0.35) | ALDH1A1KMT2AFFAR1 | |
| SCHEMBL4362453 | 0.70 | ALDH1A1 (0.43) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5041694-A | Substituted glutaric acid lactones in the treatment of hyperlipidemia | G. D. SEARLE & CO. (US) | 1991-08-20 | — | — | US | disclosed |
| US-4965373-A | Substituted glutaric acid lactones in the treatment of hyperlipidemia | G. D. SEARLE & CO. (US) | 1990-10-23 | — | — | US | disclosed |
| US-4895973-A | Substituted glutaric acid lactones in the treatment of hyperlipidemia | G. D. SEARLE & COMPANY (US) | 1990-01-23 | — | — | US | disclosed |
| EP-0194610-B1 | SUBSTITUTED GLUTARIC ACID LACTONES IN THE TREATMENT OF HYPERLIPIDEMIA | G.D. Searle & Co. (US) | 1989-02-22 | — | — | EP | disclosed |
| US-4622338-A | Substituted glutaric acid lactones in the treatment of hyperlipidemia | G. D. SEARLE & CO. (US) | 1986-11-11 | — | — | US | disclosed |
| EP-0194610-A1 | Substituted glutaric acid lactones in the treatment of hyperlipidemia | G.D. Searle & Co. (US) | 1986-09-17 | — | — | EP | disclosed |