Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10506484 | 0.81 | GPR84 (0.53) | TSHRALDH1A1GPR84KMT2A | |
| SCHEMBL1866738 | 0.81 | CYP2D6 (0.47) | TSHRCYP2D6ALDH1A1L3MBTL1NPSR1 | |
| SCHEMBL21552018 | 0.78 | GPR84 (0.46) | ALDH1A1GPR84L3MBTL1KMT2A | |
| SCHEMBL21552037 | 0.78 | GPR84 (0.46) | ALDH1A1GPR84L3MBTL1KMT2A | |
| SCHEMBL22677576 | 0.78 | GPR84 (0.46) | ALDH1A1GPR84L3MBTL1KMT2A | |
| SCHEMBL21551861 | 0.78 | GPR84 (0.46) | ALDH1A1GPR84L3MBTL1KMT2A | |
| SCHEMBL7603328 | 0.78 | GPR84 (0.46) | ALDH1A1GPR84L3MBTL1KMT2A | |
| SCHEMBL11218217 | 0.77 | ALDH1A1 (0.43) | TSHRALDH1A1L3MBTL1NPSR1KMT2A | |
| SCHEMBL6564298 | 0.76 | L3MBTL1 (0.42) | TSHRCYP2D6ALDH1A1L3MBTL1NPSR1 | |
| SCHEMBL21551847 | 0.76 | GPR84 (0.47) | TSHRALDH1A1GPR84L3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5041694-A | Substituted glutaric acid lactones in the treatment of hyperlipidemia | G. D. SEARLE & CO. (US) | 1991-08-20 | — | — | US | claimed |
| US-5041694-A | Substituted glutaric acid lactones in the treatment of hyperlipidemia | G. D. SEARLE & CO. (US) | 1991-08-20 | — | — | US | disclosed |
| US-4965373-A | Substituted glutaric acid lactones in the treatment of hyperlipidemia | G. D. SEARLE & CO. (US) | 1990-10-23 | — | — | US | disclosed |
| US-4895973-A | Substituted glutaric acid lactones in the treatment of hyperlipidemia | G. D. SEARLE & COMPANY (US) | 1990-01-23 | — | — | US | disclosed |
| EP-0194610-B1 | SUBSTITUTED GLUTARIC ACID LACTONES IN THE TREATMENT OF HYPERLIPIDEMIA | G.D. Searle & Co. (US) | 1989-02-22 | — | — | EP | disclosed |
| US-4622338-A | Substituted glutaric acid lactones in the treatment of hyperlipidemia | G. D. SEARLE & CO. (US) | 1986-11-11 | — | — | US | disclosed |