Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.47 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10507500 | 1.00 | NPBWR1 (0.51) | NPBWR1SMN1; SMN2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL10508351 | 0.94 | SMN1; SMN2 (0.50) | NPBWR1SMN1; SMN2NPSR1ALDH1A1GAA | |
| SCHEMBL10508337 | 0.94 | SMN1; SMN2 (0.50) | NPBWR1SMN1; SMN2NPSR1ALDH1A1GAA | |
| SCHEMBL10509051 | 0.89 | NPBWR1 (0.53) | NPBWR1SMN1; SMN2NPSR1ALDH1A1POLB | |
| SCHEMBL10509058 | 0.89 | NPBWR1 (0.53) | NPBWR1SMN1; SMN2NPSR1ALDH1A1POLB | |
| SCHEMBL10510119 | 0.85 | PTGS2 (0.49) | SMN1; SMN2ALDH1A1KDM4EHTTLMNA | |
| SCHEMBL10510131 | 0.85 | PTGS2 (0.49) | SMN1; SMN2ALDH1A1KDM4EHTTLMNA | |
| SCHEMBL10509004 | 0.84 | NPBWR1 (0.50) | NPBWR1SMN1; SMN2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL10509418 | 0.84 | GRM7 (0.47) | CYP3A4NPSR1ALDH1A1GAAKDM4E | |
| SCHEMBL10509429 | 0.84 | GRM7 (0.47) | CYP3A4NPSR1ALDH1A1GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0164593-B1 | ANTI-INFLAMMATORY PHTHALAZINONES | FISONS CORPORATION (US) | 1989-11-15 | — | — | EP | disclosed |
| US-4665181-A | Anti-inflammatory phthalazinones | PENNWALT CORPORATION (US) | 1987-05-12 | — | — | US | disclosed |
| EP-0164593-A1 | Anti-inflammatory phthalazinones | FISONS CORPORATION (US) | 1985-12-18 | — | — | EP | disclosed |