Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 11/20 | 0.50 |
| ▸ | MCHR1 | Q99705 | 7/20 | 0.50 |
| ▸ | RELA | Q04206 | 2/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | PDE9A | O76083 | 3/20 | 0.41 |
| ▸ | AHR | P35869 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10508995 | 1.00 | NPBWR1 (0.50) | NPBWR1MCHR1RELANFE2L2SMN1; SMN2 | |
| SCHEMBL10507488 | 0.84 | NPBWR1 (0.51) | NPBWR1SMN1; SMN2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL10507500 | 0.84 | NPBWR1 (0.51) | NPBWR1SMN1; SMN2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL10508351 | 0.83 | SMN1; SMN2 (0.50) | NPBWR1MCHR1SMN1; SMN2NPSR1NPC1 | |
| SCHEMBL10508337 | 0.83 | SMN1; SMN2 (0.50) | NPBWR1MCHR1SMN1; SMN2NPSR1NPC1 | |
| SCHEMBL10509429 | 0.81 | GRM7 (0.47) | RELACYP3A4NPSR1NPC1ALDH1A1 | |
| SCHEMBL10509418 | 0.81 | GRM7 (0.47) | RELACYP3A4NPSR1NPC1ALDH1A1 | |
| SCHEMBL10509058 | 0.78 | NPBWR1 (0.53) | NPBWR1MCHR1RELASMN1; SMN2NPSR1 | |
| SCHEMBL10509051 | 0.78 | NPBWR1 (0.53) | NPBWR1MCHR1RELASMN1; SMN2NPSR1 | |
| SCHEMBL10510131 | 0.75 | PTGS2 (0.49) | NFE2L2SMN1; SMN2NPC1S1PR4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0164593-B1 | ANTI-INFLAMMATORY PHTHALAZINONES | FISONS CORPORATION (US) | 1989-11-15 | — | — | EP | disclosed |
| US-4665181-A | Anti-inflammatory phthalazinones | PENNWALT CORPORATION (US) | 1987-05-12 | — | — | US | disclosed |