Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1151915 | 0.85 | KCNH2 (0.59) | KCNH2TSHRKDM4EGAAHSD17B10 | |
| SCHEMBL9690409 | 0.79 | KCNH2 (0.55) | KCNH2TSHRKDM4EGAAHSD17B10 | |
| SCHEMBL10749867 | 0.79 | KCNH2 (0.59) | KCNH2TSHRKDM4EGAAHSD17B10 | |
| SCHEMBL9698375 | 0.78 | KCNH2 (0.66) | KCNH2TSHRCHRNA7 | |
| Hydrochloric Acid SCHEMBL10506400 | 0.77 | SSTR5 (0.42) | KCNH2TSHR | |
| SCHEMBL8562586 | 0.76 | KCNH2 (0.65) | KCNH2TSHRCHRNA7PDE10ADRD4 | |
| SCHEMBL11266594 | 0.76 | KCNH2 (0.80) | KCNH2TSHRGAACHRNA7 | |
| SCHEMBL7416758 | 0.75 | KCNH2 (0.65) | KCNH2TSHR | |
| Water SCHEMBL8566156 | 0.73 | KCNH2 (0.61) | KCNH2 | |
| SCHEMBL8560605 | 0.73 | KCNH2 (0.61) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0145037-B1 | N-(BICYCLIC HETEROCYCLYL)-4-PIPERIDINAMINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1989-01-18 | — | — | EP | disclosed |
| EP-0145037-A2 | N-(bicyclic heterocyclyl)-4-piperidinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-06-19 | — | — | EP | disclosed |