Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 1/20 | 0.43 |
| ▸ | DAO | P14920 | 1/20 | 0.40 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 3/20 | 0.36 |
| ▸ | MAOA | P21397 | 2/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10508695 | 1.00 | AHR (0.43) | AHRDAOKCNA3CYP1A2ALOX5 | |
| SCHEMBL10506622 | 0.88 | MAOA (0.48) | DAOMAOBMAOAKDM4ERELA | |
| SCHEMBL10506627 | 0.88 | MAOA (0.48) | DAOMAOBMAOAKDM4ERELA | |
| SCHEMBL10507593 | 0.83 | MEN1 (0.48) | CYP1A2MAOBMAOAKDM4EMAPT | |
| SCHEMBL10507599 | 0.83 | MEN1 (0.48) | CYP1A2MAOBMAOAKDM4EMAPT | |
| SCHEMBL30546243 | 0.82 | S100A4 (0.41) | KDM4EMAPTRETKDR | |
| SCHEMBL87581 | 0.82 | S100A4 (0.41) | KDM4EMAPTRETKDR | |
| SCHEMBL10507526 | 0.82 | RELA (0.48) | AHRCYP1A2ALOX5PTGS1PTGS2 | |
| SCHEMBL10507533 | 0.82 | RELA (0.48) | AHRCYP1A2ALOX5PTGS1PTGS2 | |
| SCHEMBL10509366 | 0.81 | CYP19A1 (0.51) | PTGS1PTGS2MAOBNPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0164593-B1 | ANTI-INFLAMMATORY PHTHALAZINONES | FISONS CORPORATION (US) | 1989-11-15 | — | — | EP | disclosed |
| US-4665181-A | Anti-inflammatory phthalazinones | PENNWALT CORPORATION (US) | 1987-05-12 | — | — | US | disclosed |
| EP-0164593-A1 | Anti-inflammatory phthalazinones | FISONS CORPORATION (US) | 1985-12-18 | — | — | EP | disclosed |