Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | HTR2A | P28223 | 5/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | CASP3 | P42574 | 2/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2085643 | 0.77 | RAB9A (0.50) | RAB9ANPC1KDM4EMAPTMEN1 | |
| SCHEMBL31181951 | 0.77 | RAB9A (0.50) | RAB9ANPC1KDM4EMAPTMEN1 | |
| SCHEMBL2007176 | 0.76 | RIPK1 (0.48) | — | |
| SCHEMBL1174412 | 0.75 | RAB9A (0.49) | RAB9ANPC1KDM4EMAPTMEN1 | |
| SCHEMBL5138986 | 0.74 | SIGMAR1 (0.51) | RAB9ANPC1HTR2AHTR2CKDM4E | |
| SCHEMBL31341971 | 0.72 | CHEK1 (0.39) | HTR2AHTR2CHTR2BKDRCHEK1 | |
| SCHEMBL374022 | 0.72 | RAB9A (0.74) | RAB9ANPC1KDM4EMAPTMEN1 | |
| SCHEMBL29631691 | 0.72 | RAB9A (0.74) | RAB9ANPC1KDM4EMAPTMEN1 | |
| SCHEMBL14498916 | 0.72 | KDR (0.47) | RAB9ANPC1KDM4EMAPTMEN1 | |
| SCHEMBL25452804 | 0.70 | ADRA2A (0.58) | HTR2AHTR2CHTR2BADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0169148-B1 | INDOLE DERIVATIVES, THEIR PREPARATION, THEIR USE AS MEDICINES AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1989-09-13 | — | — | EP | disclosed |