Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL11225817 | 0.95 | ALDH1A1 (0.48) | ALDH1A1MAPTKDM4ETDP1LMNA | |
| SCHEMBL11220939 | 0.86 | DRD2 (0.41) | ALDH1A1MAPTKDM4ETDP1ADRB1 | |
| SCHEMBL11150638 | 0.82 | OPRM1 (0.53) | OPRM1 | |
| SCHEMBL11153193 | 0.81 | L3MBTL1 (0.47) | ALDH1A1LMNASIRT6L3MBTL1SMN1; SMN2 | |
| SCHEMBL26413607 | 0.80 | ALDH1A1 (0.47) | ALDH1A1MAPTKDM4ETDP1LMNA | |
| SCHEMBL26413454 | 0.79 | CES1 (0.46) | MAPTTDP1L3MBTL1MEN1MAPK1 | |
| SCHEMBL11150886 | 0.78 | CYP2D6 (0.47) | ALDH1A1KDM4ETDP1OPRM1L3MBTL1 | |
| SCHEMBL11158087 | 0.78 | KCNH2 (0.47) | ALDH1A1LMNAOPRM1HTTL3MBTL1 | |
| SCHEMBL11159483 | 0.78 | OPRM1 (0.44) | ALDH1A1OPRM1SMN1; SMN2KMT2A | |
| SCHEMBL23410201 | 0.78 | ADRB1 (0.45) | ALDH1A1MAPTKDM4ETDP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0333025-A1 | 1-Carbonylderivatives of 4-aryl-4-aryloxypiperidines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1989-09-20 | — | — | EP | disclosed |
| US-4853384-A | ANTICONVULSANTS; | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1989-08-01 | — | — | US | disclosed |
| EP-0023706-B1 | 4-PHENOXY PIPERIDINES, PROCESS FOR THEIR PREPARATION, THEIR USE AND MEDICAMENTS CONTAINING THEM | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1983-03-02 | — | — | EP | disclosed |
| US-4333942-A | Anti-depressant and analgesic 4-phenoxypiperidines | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1982-06-08 | — | — | US | disclosed |
| US-4325953-A | 4-Aryl-4-aryloxypiperidines | JOHN WYETH AND BROTHER LIMITED (GB) | 1982-04-20 | — | — | US | disclosed |
| EP-0023706-A1 | 4-Phenoxy piperidines, process for their preparation, their use and medicaments containing them | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1981-02-11 | — | — | EP | disclosed |