Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 3/20 | 0.46 |
| ▸ | FAAH | O00519 | 2/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10513647 | 0.88 | TRPM8 (0.43) | CHRM4FAAHEPHX2DRD2OPRM1 | |
| SCHEMBL10516337 | 0.88 | TACR1 (0.52) | FAAHEPHX2DRD2LMNAOPRM1 | |
| SCHEMBL10516317 | 0.84 | DRD2 (0.46) | CHRM4DRD2LMNAOPRM1OPRL1 | |
| SCHEMBL10513911 | 0.82 | KMT2A (0.55) | FAAHLMNAHTTGAACYP3A4 | |
| SCHEMBL10513079 | 0.79 | FKBP1A (0.41) | FAAHEPHX2GRIN2BSMN1; SMN2ALDH1A1 | |
| SCHEMBL10515329 | 0.78 | TRPM8 (0.57) | FAAHEPHX2MAPTCYP3A4 | |
| SCHEMBL10513175 | 0.76 | HDAC3 (0.43) | OPRM1SMN1; SMN2CYP3A4CYP2C19POLB | |
| SCHEMBL10515488 | 0.75 | TACR1 (0.49) | EPHX2DRD2OPRM1OPRL1CYP2C19 | |
| SCHEMBL10512960 | 0.75 | TACR1 (0.52) | EPHX2DRD2OPRM1OPRL1GAA | |
| SCHEMBL10515881 | 0.74 | TACR1 (0.52) | DRD2TACR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4853384-A | ANTICONVULSANTS; | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1989-08-01 | — | — | US | claimed |
| EP-0333025-A1 | 1-Carbonylderivatives of 4-aryl-4-aryloxypiperidines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1989-09-20 | — | — | EP | disclosed |
| US-4853384-A | ANTICONVULSANTS; | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1989-08-01 | — | — | US | disclosed |