Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 6/20 | 0.57 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.56 |
| ▸ | NAMPT | P43490 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | FAAH | O00519 | 1/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.48 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.48 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.48 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.48 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.48 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.48 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10513647 | 0.85 | TRPM8 (0.43) | TRPM8TRPV1THRBFAAHEPHX2 | |
| SCHEMBL2724878 | 0.82 | TRPV1 (0.63) | TRPM8TRPV1NAMPTTHRBFAAH | |
| SCHEMBL11740042 | 0.82 | CYP3A4 (0.48) | TRPV1CYP3A4 | |
| SCHEMBL10514541 | 0.81 | THRB (0.41) | TRPM8THRBEPHX2 | |
| SCHEMBL10515488 | 0.81 | TACR1 (0.49) | EPHX2 | |
| SCHEMBL10512960 | 0.81 | TACR1 (0.52) | THRBEPHX2 | |
| SCHEMBL10515742 | 0.79 | OPRM1 (0.44) | THRBEPHX2 | |
| SCHEMBL10514775 | 0.78 | CHRM4 (0.46) | FAAHEPHX2CYP3A4MAPT | |
| SCHEMBL10513297 | 0.77 | CYP2C19 (0.52) | TRPM8CYP3A4MAPT | |
| SCHEMBL11224032 | 0.74 | DRD2 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0333025-A1 | 1-Carbonylderivatives of 4-aryl-4-aryloxypiperidines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1989-09-20 | — | — | EP | disclosed |
| US-4853384-A | ANTICONVULSANTS; | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1989-08-01 | — | — | US | disclosed |