Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 1/20 | 0.49 |
| ▸ | RORC | P51449 | 6/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 3/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10512960 | 0.95 | TACR1 (0.52) | TACR1RORCDRD2USP2CYP2C19 | |
| SCHEMBL10516337 | 0.87 | TACR1 (0.52) | TACR1DRD2USP2CYP2C19ALDH1A1 | |
| SCHEMBL10513967 | 0.85 | USP2 (0.46) | USP2CYP2C19ALDH1A1MAPK1CYP1A2 | |
| SCHEMBL11740042 | 0.83 | CYP3A4 (0.48) | USP2CYP2C19ALDH1A1MAPK1CYP1A2 | |
| SCHEMBL10514541 | 0.83 | THRB (0.41) | TACR1DRD2ALDH1A1OPRM1OPRL1 | |
| SCHEMBL10513647 | 0.82 | TRPM8 (0.43) | TACR1DRD2USP2OPRM1OPRL1 | |
| SCHEMBL10515742 | 0.82 | OPRM1 (0.44) | TACR1DRD2OPRM1OPRL1EPHX2 | |
| SCHEMBL10515329 | 0.81 | TRPM8 (0.57) | EPHX2 | |
| SCHEMBL11224032 | 0.78 | DRD2 (0.50) | TACR1DRD2OPRM1OPRL1 | |
| SCHEMBL10483337 | 0.78 | TACR1 (0.47) | TACR1DRD2USP2CYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0333025-A1 | 1-Carbonylderivatives of 4-aryl-4-aryloxypiperidines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1989-09-20 | — | — | EP | disclosed |
| US-4853384-A | ANTICONVULSANTS; | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1989-08-01 | — | — | US | disclosed |