Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5694910 | 0.73 | SIGMAR1 (0.48) | MAPTALDH1A1TDP1CYP2D6 | |
| SCHEMBL12486958 | 0.72 | LTA4H (0.58) | LTA4HALDH1A1KDM4EHRH3SMN1; SMN2 | |
| SCHEMBL2300940 | 0.72 | LTA4H (0.53) | LTA4HALDH1A1KDM4EHRH3SMN1; SMN2 | |
| SCHEMBL255055 | 0.72 | ESR1 (0.58) | LTA4HALDH1A1KMT2AKDM4EHRH3 | |
| SCHEMBL3154476 | 0.71 | HRH3 (0.57) | LTA4HALDH1A1KDM4EHRH3SMN1; SMN2 | |
| SCHEMBL10407980 | 0.67 | NAAA (0.47) | ALDH1A1MEN1KMT2A | |
| SCHEMBL11728275 | 0.64 | ALDH1A1 (0.38) | LTA4HPDK1ALDH1A1MEN1KMT2A | |
| SCHEMBL8469734 | 0.64 | POLB (0.51) | ALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL27945286 | 0.64 | LTA4H (0.54) | MAPTLTA4HALDH1A1MEN1KMT2A | |
| SCHEMBL6003334 | 0.63 | KCNA3 (0.48) | LTA4HALDH1A1MEN1KMT2AKCNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0310061-A1 | 5-Mono or Disubstituted-3-(phenyl or 2-naphthalenyl)-3-[(1H-imidazol-1-ylmethyl) or (1H-1,2,4-triazol-1-ylmethyl)]-2-(methyl or benzyl)isoxazolidines | FISONS CORPORATION (US) | 1989-04-05 | — | — | EP | disclosed |
| EP-0257351-A2 | 3-Phenyl-3-(1H-1,2,4-triazol-1-ylmethyl)-5-substituted-2-methyl-isoxazolidines | FISONS CORPORATION (a Massachusetts corporation) (US) | 1988-03-02 | — | — | EP | disclosed |