Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 4/20 | 0.39 |
| ▸ | PSMB5 | P28074 | 3/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | CAPN1 | P07384 | 4/20 | 0.36 |
| ▸ | CMA1 | P23946 | 1/20 | 0.36 |
| ▸ | CTRC | Q99895 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 2/20 | 0.35 |
| ▸ | REN | P00797 | 2/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | CCKBR | P32239 | 2/20 | 0.35 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.34 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10519172 | 0.89 | REN (0.40) | MMP8CAPN1CTSLREN | |
| SCHEMBL10897999 | 0.84 | PSMB5 (0.45) | CTSBPSMB5MMP8RENPSMB1 | |
| SCHEMBL10522964 | 0.82 | REN (0.35) | CTSBPSMB5MMP8CAPN1REN | |
| SCHEMBL10522966 | 0.82 | REN (0.35) | CTSBPSMB5MMP8CAPN1REN | |
| SCHEMBL10521374 | 0.81 | CAPN1 (0.48) | CTSBPSMB5MMP8CAPN1CTSL | |
| SCHEMBL10633448 | 0.79 | REN (0.56) | CTSBPSMB5CTSLRENPSMB1 | |
| SCHEMBL10521381 | 0.79 | PSMB5 (0.42) | PSMB5MMP8CTSLREN | |
| SCHEMBL10520558 | 0.78 | MMP9 (0.47) | MMP8REN | |
| SCHEMBL10520279 | 0.78 | CAPN1 (0.47) | PSMB5MMP8CAPN1CTSLREN | |
| SCHEMBL10520198 | 0.78 | CAPN1 (0.50) | CTSBCAPN1CTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4863904-A | Dipeptides as renin inhibitors | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1989-09-05 | — | — | US | disclosed |
| EP-0181110-A2 | Histidine derivatives as renin inhibitors | Kissei Pharmaceutical Co. Ltd. (JP) | 1986-05-14 | — | — | EP | disclosed |