Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 11/20 | 0.40 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.39 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | FCER2 | P06734 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10520337 | 0.89 | CTSB (0.39) | RENCAPN1CTSLMMP8 | |
| SCHEMBL10522964 | 0.84 | REN (0.35) | RENCAPN1MMP9MMP8 | |
| SCHEMBL10522966 | 0.84 | REN (0.35) | RENCAPN1MMP9MMP8 | |
| SCHEMBL10521374 | 0.84 | CAPN1 (0.48) | RENCAPN1CTSLMMP1FCER2 | |
| SCHEMBL10520558 | 0.82 | MMP9 (0.47) | RENMMP1FCER2MMP9MMP8 | |
| SCHEMBL10521381 | 0.81 | PSMB5 (0.42) | RENCTSLMMP1FCER2MMP9 | |
| SCHEMBL10521185 | 0.80 | CASP1 (0.47) | RENCAPN1MMP9MMP8 | |
| SCHEMBL10897999 | 0.79 | PSMB5 (0.45) | RENMMP1FCER2MMP9MMP8 | |
| SCHEMBL10519910 | 0.79 | CAPN1 (0.52) | RENCAPN1CTSLMMP1MMP9 | |
| SCHEMBL10520279 | 0.79 | CAPN1 (0.47) | RENCAPN1CTSLMMP1MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4863904-A | Dipeptides as renin inhibitors | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1989-09-05 | — | — | US | disclosed |
| EP-0181110-A2 | Histidine derivatives as renin inhibitors | Kissei Pharmaceutical Co. Ltd. (JP) | 1986-05-14 | — | — | EP | disclosed |