SCHEMBL1052041

SCHEMBL1052041

C[Si](C)(C)C1CC=CCC1

nearest known ligand 0.36

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.36
ALOX15 P16050 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6291623 0.85
SCHEMBL14559750 0.80 ALDH1A1 (0.33) ALDH1A1ALOX15
SCHEMBL6294462 0.80
SCHEMBL27957266 0.77 ALDH1A1 (0.31) ALDH1A1ALOX15
SCHEMBL11072482 0.77 ALDH1A1 (0.31) ALDH1A1ALOX15
SCHEMBL11073034 0.77 ALDH1A1 (0.31) ALDH1A1ALOX15
SCHEMBL11072025 0.75 ALDH1A1 (0.30) ALDH1A1ALOX15
SCHEMBL983841 0.74 ALDH1A1 (0.36) ALDH1A1ALOX15
SCHEMBL1050477 0.73 ALDH1A1 (0.32) ALDH1A1ALOX15
SCHEMBL8143210 0.69

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3141538-B1 IMPROVED PROCESS STABILITY OF NBDE USING SUBSTITUTED PHENOL STABILIZERS VERSUM MAT US LLC (US) 2019-10-30 EP disclosed
EP-2318477-B1 ADDITIVES TO PREVENT DEGRADATION OF CYCLIC ALKENE DERIVATIVES FUJIFILM ELECTRONIC MAT USA INC (US) 2019-06-05 EP disclosed
EP-3141538-A1 IMPROVED PROCESS STABILITY OF NBDE USING SUBSTITUTED PHENOL STABILIZERS AIR PRODUCTS AND CHEMICALS, INC. (US) 2017-03-15 EP disclosed
EP-2141141-B1 Improved Process Stability of NBDE Using Substituted Phenol Stabilizers AIR PROD & CHEM (US) 2016-09-28 EP disclosed
EP-1931613-B1 ADDITIVES TO PREVENT DEGRADATION OF CYCLIC ALKENE DERIVATIVES FUJIFILM ELECTRONIC MATERIALS (US) 2015-11-11 EP disclosed
CN-102089405-B Additives to prevent degradation of cyclic alkene derivatives FUJIFILM ELECTRONIC MATERIALS 2013-10-16 CN disclosed
EP-1931746-B1 ADDITIVES TO PREVENT DEGRADATION OF CYCLIC ALKENE DERIVATIVES FUJIFILM ELECTRONIC MATERIALS (US) 2013-09-04 EP disclosed
US-8252704-B2 Additives to prevent degradation of cyclic alkene derivatives FUJIFILM ELECTRONIC MATERIALS U.S.A., INC. (US) 2012-08-28 US disclosed
CN-101591772-B Process stability of nbde using substituted phenol stabilizers AIR PROD & CHEM 2012-07-04 CN disclosed
US-8173213-B2 Process stability of NBDE using substituted phenol stabilizers AIR PRODUCTS AND CHEMICALS, INC. (US) 2012-05-08 US disclosed
CN-1451009-A Glucocortiocoid-selective antinflammatory agents ABBOTT LAB (US) 2003-10-22 CN disclosed
CN-1119348-C glucocorticoid derivatives, compositions and uses thereof ABBOTT INC (US) 2003-08-27 CN disclosed
US-20030073703-A1 Glucocortiocoid-selective antinflammatory agents ABBOTT LABORATORIES AND LIGAND PHARMACEUTICALS INCORPORATED 2003-04-17 US disclosed
EP-1299392-A2 GLUCOCORTIOCOID-SELECTIVE ANTIINFLAMMATORY AGENTS Abbott Laboratories (US) 2003-04-09 EP disclosed
US-6506766-B1 A pharmaceutical composition for use in treating inflammation, immune, autoimmune, and inflammatory diseases in a mammal by selectively modulating the activation, repression, agonism, and antagonism effects of the mammal's glucocorticoid ABBOTT LABORATORIES 2003-01-14 US disclosed
EP-1053239-B1 GLUCOCORTICOID-SELECTIVE ANTI-INFLAMMATORY AGENTS ABBOTT LAB (US) 2003-01-08 EP disclosed
WO-2002002565-A2 GLUCOCORTIOCOID-SELECTIVE ANTIINFLAMMATORY AGENTS ABBOTT LABORATORIES (US) 2002-01-10 WO disclosed
CN-1296486-A Glucocorticoid-selective anti-inflammatory agents ABBOTT LAB (US) 2001-05-23 CN disclosed
US-4870062-A REDUCED NEPHROTOXICITY SANWA KAGAKU KENKYUSHO CO., LTD. (JP) 1989-09-26 US disclosed
EP-0288002-A2 Organo-platinum complex and use thereof SANWA KAGAKU KENKYUSHO CO., LTD. (JP) 1988-10-26 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030073703-A1 Glucocortiocoid-selective antinflammatory agents NR3C1, GPR119, MC2R ALDH1A1 3187/4885ALOX15 491/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.