SCHEMBL1053699

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL4719272	0.84	ITK (0.43)	KMT2ANR1H2NR1H3EGFRITK
	SCHEMBL10117911	0.78	PIK3CD (0.43)	NR1H2NR1H3PIK3CDABL1EGFR
	SCHEMBL3835028	0.77	MAPT (0.43)	KMT2AMEN1NR1H2PIK3CDABL1
	SCHEMBL2458509	0.77	ACLY (0.52)	NR1H2NR1H3PIK3CDABL1EGFR
	SCHEMBL15969036	0.77	PPARG (0.43)	NR1H2NR1H3PIK3CDABL1EGFR
	SCHEMBL6394140	0.76	PIK3CD (0.45)	PIK3CDABL1EGFRHCKSRC
	SCHEMBL17782354	0.76	NR1H2 (0.42)	NR1H2NR1H3PIK3CDABL1EGFR
	SCHEMBL5482233	0.76	HTR6 (0.41)	KMT2AMEN1NR1H2NR1H3PIK3CD
	SCHEMBL1053697	0.76	ALDH1A1 (0.46)	NR1H2PIK3CDABL1EGFRHCK
	SCHEMBL691666	0.74	NOTUM (0.59)	NR1H2NR1H3PIK3CDABL1EGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.