Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ENPP3 | O14638 | 2/20 | 0.39 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.39 |
| ▸ | AMY1A | P0DUB6 | 2/20 | 0.38 |
| ▸ | KMO | O15229 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10556563 | 0.74 | PTGS2 (0.47) | MAPTTP53PTGS2PTGS1KDM4E | |
| SCHEMBL8201677 | 0.73 | PTGS2 (0.44) | PTGS2PTGS1KDM4EKMOMEN1 | |
| SCHEMBL12326172 | 0.68 | PTGS2 (0.53) | PTGS2PTGS1KMOMEN1ALDH1A1 | |
| SCHEMBL9217797 | 0.68 | NPBWR1 (0.38) | THRBPTGS1KDM4EENPP3ENPP1 | |
| SCHEMBL12130381 | 0.65 | KMO (0.44) | PTGS2PTGS1KDM4EKMOMEN1 | |
| SCHEMBL6002654 | 0.65 | SMPD3 (0.56) | MAPTKDM4EKMOALDH1A1ADORA2A | |
| SCHEMBL30096868 | 0.65 | TBK1 (0.42) | MAPTTP53THRBKDM4ETBK1 | |
| SCHEMBL31305536 | 0.65 | SMPD3 (0.51) | MAPTKDM4ECHEK2AMY1AALOX5 | |
| SCHEMBL26134931 | 0.65 | SMPD3 (0.51) | MAPTKDM4ECHEK2AMY1AALOX5 | |
| SCHEMBL8715460 | 0.65 | MAPT (0.49) | MAPTTP53THRBPTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4853383-A | β-blocking substituted imidazoles | MERCK & CO., INC. (US) | 1989-08-01 | — | — | US | disclosed |
| US-4642311-A | β-adrenergic blocking imidazolylphenoxy propanolamines | MERCK & CO., INC. (US) | 1987-02-10 | — | — | US | disclosed |