Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | SI | P14410 | 3/20 | 0.45 |
| ▸ | MGAM2 | Q2M2H8 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CTSV | O60911 | 2/20 | 0.43 |
| ▸ | CTSL | P07711 | 2/20 | 0.43 |
| ▸ | ERN1 | O75460 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | LIPE | Q05469 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28108814 | 0.90 | ABCB1 (0.50) | MGAMGAASIMGAM2HSD17B10 | |
| SCHEMBL1056954 | 0.89 | KDM1A (0.43) | LMNAHTTHPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL2303383 | 0.83 | KDM1A (0.48) | LMNAHPGDSMN1; SMN2NPC1MAOB | |
| SCHEMBL21722716 | 0.83 | GAA (0.45) | MGAMGAASIMGAM2HSD17B10 | |
| SCHEMBL1055726 | 0.82 | ALDH1A1 (0.44) | LMNAHTTHPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL9075448 | 0.82 | ABCB1 (0.47) | MGAMGAASIMGAM2 | |
| SCHEMBL4420078 | 0.81 | LIPE (0.47) | HSD17B10LMNAHPGDSMN1; SMN2MAPK1 | |
| SCHEMBL1766201 | 0.81 | RXRA (0.55) | HPGDSMN1; SMN2NPC1RAB9A | |
| SCHEMBL7511997 | 0.80 | HSD17B10 (0.58) | MGAMGAASIMGAM2HSD17B10 | |
| SCHEMBL7283121 | 0.80 | HTR2A (0.48) | HSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7872014-B2 | Anaplastic lymphoma kinase modulators and methods of use | EXELIXIS, INC. (US) | 2011-01-18 | — | — | US | disclosed |
| US-20070032515-A1 | Anaplastic lymphoma kinase modulators and methods of use | EXELIXIS, INC. (US) | 2007-02-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070032515-A1 | Anaplastic lymphoma kinase modulators and methods of use | ALK, MALT1, BCL6 | MGAM 2947/4885GAA 957/4885SI 4403/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.