SCHEMBL10557151

SCHEMBL10557151

C[Si](C)(CSCc1cccc(Oc2ccccc2)n1)c1ccc(Cl)cc1

nearest known ligand 0.35

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.35
LMNA P02545 2/20 0.35
HPGD P15428 1/20 0.35
HTT P42858 2/20 0.35
P2RX3 P56373 5/20 0.34
MEN1 O00255 4/20 0.33
KMT2A Q03164 4/20 0.33
KCNH2 Q12809 2/20 0.33
NPC1 O15118 2/20 0.33
RAB9A P51151 2/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
GAA P10253 1/20 0.33
NPSR1 Q6W5P4 1/20 0.32
MAPK1 P28482 2/20 0.32
TSHR P16473 2/20 0.32
MRGPRX4 Q96LA9 1/20 0.32
TDP1 Q9NUW8 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10554877 0.88 LOXL2 (0.37) L3MBTL1HPGDHTTMEN1KMT2A
SCHEMBL10551981 0.86 LTA4H (0.46) L3MBTL1LMNAHPGDMEN1KMT2A
SCHEMBL10552971 0.78 CYP1A2 (0.44) LMNAHPGDHTTKCNH2NPC1
SCHEMBL9785579 0.71 P2RX3 (0.45) L3MBTL1HTTP2RX3MEN1KMT2A
SCHEMBL7169249 0.70 KCNH2 (0.41) L3MBTL1HPGDHTTMEN1KMT2A
SCHEMBL28015517 0.70 MEN1 (0.46) L3MBTL1HPGDHTTP2RX3MEN1
SCHEMBL9519763 0.69 KCNH2 (0.44) L3MBTL1HPGDHTTMEN1KMT2A
SCHEMBL9198043 0.69 KCNH2 (0.44) L3MBTL1HPGDHTTMEN1KMT2A
SCHEMBL9818056 0.68 P2RX3 (0.53) L3MBTL1HTTP2RX3MEN1KMT2A
SCHEMBL10550041 0.68 KCNH2 (0.43) L3MBTL1LMNAHPGDHTTP2RX3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4804653-A INSECTICIDES, MITICIDES UNIROYAL CHEMICAL COMPANY, INC. (US) 1989-02-14 US claimed
US-4804653-A INSECTICIDES, MITICIDES UNIROYAL CHEMICAL COMPANY, INC. (US) 1989-02-14 US disclosed