Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 6/20 | 0.40 |
| ▸ | MMP13 | P45452 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.36 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.36 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.36 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.35 |
| ▸ | GPR3 | P46089 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydroxyurea SCHEMBL10559837 | 0.74 | MAPT (0.42) | MMP12MMP13MAPTALDH1A1HPGD | |
| SCHEMBL10559606 | 0.73 | ALOX5 (0.41) | MMP12MMP13MAPTALDH1A1HPGD | |
| SCHEMBL6387827 | 0.73 | ALOX5 (0.48) | HDAC1HDAC8HDAC6CYP1A2HDAC3 | |
| SCHEMBL11248448 | 0.73 | AKR1B1 (0.55) | MMP12MMP13MAPTALDH1A1HPGD | |
| SCHEMBL8610327 | 0.72 | ALDH1A1 (0.50) | MMP12MMP13MAPTALDH1A1HPGD | |
| SCHEMBL13338346 | 0.71 | GPR3 (0.54) | MMP12MMP13MAPTALDH1A1HPGD | |
| SCHEMBL9764874 | 0.70 | MAPT (0.37) | MMP12MMP13MAPTALDH1A1HPGD | |
| SCHEMBL25721015 | 0.69 | ALDH1A1 (0.50) | MMP12MMP13MAPTALDH1A1HPGD | |
| SCHEMBL10560605 | 0.69 | ALOX5 (0.44) | MAPTALDH1A1HPGDRAB9ASMN1; SMN2 | |
| Ammonia Solution, Strong SCHEMBL10593725 | 0.68 | ALOX5 (0.43) | MAPTALDH1A1HPGDRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0346939-A1 | Tricyclic lipoxygenase inhibiting compounds | ABBOTT LABORATORIES (US) | 1989-12-20 | — | — | EP | disclosed |
| US-4822811-A | Carbazole lipoxygenase inhibiting compounds, compositions and use | ABBOTT LABORATORIES (US) | 1989-04-18 | — | — | US | disclosed |