Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 1/20 | 0.49 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.46 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.46 |
| ▸ | ITGAV | P06756 | 1/20 | 0.46 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 9/20 | 0.45 |
| ▸ | PPARG | P37231 | 8/20 | 0.45 |
| ▸ | PPARD | Q03181 | 2/20 | 0.43 |
| ▸ | CTSS | P25774 | 3/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1055857 | 1.00 | ACE (0.49) | ACEITGB3ITGA2BITGB1ITGAV | |
| SCHEMBL13316851 | 0.90 | CTSS (0.40) | ACEITGB3ITGA2BITGB1ITGAV | |
| SCHEMBL1056763 | 0.89 | KLK5 (0.45) | ACEITGB3ITGA2BITGB1ITGAV | |
| SCHEMBL1056766 | 0.89 | KLK5 (0.45) | ACEITGB3ITGA2BITGB1ITGAV | |
| SCHEMBL28385047 | 0.88 | ACE (0.47) | ACEITGB3ITGA2BITGB1ITGAV | |
| SCHEMBL12600964 | 0.88 | ACE (0.42) | ACEITGB3ITGA2BITGB1ITGAV | |
| SCHEMBL28102485 | 0.88 | PPARA (0.43) | ACEITGB3ITGA2BITGB1ITGAV | |
| SCHEMBL28385045 | 0.88 | ACE (0.47) | ACEITGB3ITGA2BITGB1ITGAV | |
| SCHEMBL19720147 | 0.88 | PPARA (0.43) | ACEITGB3ITGA2BITGB1ITGAV | |
| SCHEMBL10604860 | 0.87 | ACE (0.53) | ACEITGB3ITGA2BITGB1ITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 92 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190177281-A1 | PROCESS FOR THE PREPARATION OF 5-[[[(2S)-2-AMINO-3-[4-(AMINOCARBONYL)-2,6-DIMETHYLPHENYL]-1-OXOPROPYL] [(1S)-1-(4-PHENYL-1H-IMIDAZOL-2-YL)ETHYL]AMINO] METHYL-2-METHOXYBENZOIC ACID AND ITS POLYMORPHS THEREOF | MSN LABORATORIES PRIVATE LIMITED (IN) | 2019-06-13 | — | — | US | claimed |
| WO-2017191650-A1 | PROCESS FOR THE PREPARATION OF 5-[[[(2S)-2-AMINO-3-[4-(AMINOCARBONYL)-2,6-DIMETHYLPHENYL]-1-OXOPROPYL][(1S)-1-(4-PHENYL-1H-IMIDAZOL-2-YL)ETHYL]AMINO]METHYL-2-METHOXYBENZOIC ACID AND ITS POLYMORPHS THEREOF | MSN LABORATORIES PRIVATE LIMITED (IN) | 2017-11-09 | — | — | WO | claimed |
| US-12637431-B2 | Process for the preparation of 5-[[[(2S)-2-amino-3-[4-(aminocarbonyl)-2,6-dimethylphenyl]-1-oxopropyl] [(1S)-1-(4-phenyl-1H-imidazol-2-yl)ethyl]amino] methyl-2-methoxybenzoic acid and its polymorphs thereof | MSN LABORATORIES PRIVATE LIMITED, R&D CENTER (IN) | 2026-05-26 | — | — | US | disclosed |
| CN-110093382-B | Chemical-biological preparation method of illicit-lin chiral intermediate | 尚科生物医药（上海）有限公司 | 2023-08-29 | — | — | CN | disclosed |
| CN-110092735-B | Preparation method of L-alanine derivative | 尚科生物医药（上海）有限公司 | 2021-05-11 | — | — | CN | disclosed |
| CN-108026032-B | Method for producing optically active 4-carbamoyl-2, 6-dimethylphenylalanine derivative | 株式会社钟化 | 2020-09-29 | — | — | CN | disclosed |
| CN-106636241-B | Method for preparing esmollin intermediate by enzyme method | 尚科生物医药（上海）有限公司 | 2020-04-03 | — | — | CN | disclosed |
| CN-106636246-B | Biological method for preparing (S) -1- (5-phenyl-1H-imidazole-2-yl) ethylamine | 尚科生物医药（上海）有限公司 | 2020-03-24 | — | — | CN | disclosed |
| US-10479769-B2 | Processes for the preparation of eluxadoline | SUN PHARMACEUTICAL INDUSTRIES LIMITED (IN) | 2019-11-19 | — | — | US | disclosed |
| US-20190248748-A1 | PROCESSES FOR THE PREPARATION OF ELUXADOLINE | SUN PHARMACEUTICAL INDUSTRIES LIMITED (IN) | 2019-08-15 | — | — | US | disclosed |
| US-20190177281-A1 | PROCESS FOR THE PREPARATION OF 5-[[[(2S)-2-AMINO-3-[4-(AMINOCARBONYL)-2,6-DIMETHYLPHENYL]-1-OXOPROPYL] [(1S)-1-(4-PHENYL-1H-IMIDAZOL-2-YL)ETHYL]AMINO] METHYL-2-METHOXYBENZOIC ACID AND ITS POLYMORPHS THEREOF | MSN LABORATORIES PRIVATE LIMITED (IN) | 2019-06-13 | — | — | US | disclosed |
| WO-2006099060-A2 | PROCESS FOR THE PREPARATION OF OPIOID MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-09-21 | — | — | WO | disclosed |
| US-7041681-B2 | Compounds as opioid receptor modulators | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-05-09 | — | — | US | disclosed |
| US-20060030558-A1 | Novel compounds as opioid receptor modulators | BRESLIN HENRY J | 2006-02-09 | — | — | US | disclosed |
| WO-2005090315-A1 | NOVEL COMPOUNDS AS OPIOID RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA, N. V. (BE) | 2005-09-29 | — | — | WO | disclosed |
| US-20050203143-A1 | use as pain relievers, gastrointestinal disorders such as inflammatory bowel disease; compounds are aminoacetamide derivatives substituted with an imidazole; 5-(([2-Amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1H-imidazol-2-yl)-ethyl]-amino)-methyl)-2-methoxy-benzoic acid for example | JANSSEN PHARMACEUTICA, N. V. (BE) | 2005-09-15 | — | — | US | disclosed |
| US-20050187252-A1 | 2-Amino-3-(4-hydroxy-phenyl)-1-[2-(5-phenyl-oxazol-2-yl)-piperidin-1-yl]-propan-1-one; pain and gastrointestinal disorders | BRESLIN HENRY J (US) | 2005-08-25 | — | — | US | disclosed |
| EP-1499313-A2 | HETEROCYCLIC DERIVATIVES AS OPIOID RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-01-26 | — | — | EP | disclosed |
| US-20040010014-A1 | Novel compounds as opioid receptor modulators | JANSSEN PHARMACEUTICA, NV (BE) | 2004-01-15 | — | — | US | disclosed |
| WO-2003092688-A2 | HETEROCYCLIC DERIVATIVES AS OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190248748-A1 | PROCESSES FOR THE PREPARATION OF ELUXADOLINE | CYP3A5, AVPR2, CYP3A4 | ACE 377/4885ITGB3 2980/4885ITGA2B 2492/4885 |
| US-20050203143-A1 | use as pain relievers, gastrointestinal disorders such as inflammatory bowel disease; compounds are aminoacetamide derivatives substituted with an imidazole; 5-(([2-Amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1H-imidazol-2-yl)-ethyl]-amino)-methyl)-2-methoxy-benzoic acid for example | OPRK1, OPRM1, OPRL1 | ACE 2301/4885ITGB3 3465/4885ITGA2B 2581/4885 |
| US-20060030558-A1 | Novel compounds as opioid receptor modulators | OPRL1, OPRK1, OPRM1 | ACE 3541/4885ITGB3 2971/4885ITGA2B 2460/4885 |
| US-20190177281-A1 | PROCESS FOR THE PREPARATION OF 5-[[[(2S)-2-AMINO-3-[4-(AMINOCARBONYL)-2,6-DIMETHYLPHENYL]-1-OXOPROPYL] [(1S)-1-(4-PHENYL-1H-IMIDAZOL-2-YL)ETHYL]AMINO] METHYL-2-METHOXYBENZOIC ACID AND ITS POLYMORPHS THEREOF | CYP1B1, CYP1A1, CYP4B1 | ACE 729/4885ITGB3 2190/4885ITGA2B 334/4885 |
| US-20050187252-A1 | 2-Amino-3-(4-hydroxy-phenyl)-1-[2-(5-phenyl-oxazol-2-yl)-piperidin-1-yl]-propan-1-one; pain and gastrointestinal disorders | OPRL1, OPRK1, OPRD1 | ACE 3236/4885ITGB3 2093/4885ITGA2B 2193/4885 |
| US-20040010014-A1 | Novel compounds as opioid receptor modulators | OPRL1, OPRK1, OPRM1 | ACE 3541/4885ITGB3 2971/4885ITGA2B 2460/4885 |
| US-12637431-B2 | Process for the preparation of 5-[[[(2S)-2-amino-3-[4-(aminocarbonyl)-2,6-dimethylphenyl]-1-oxopropyl] [(1S)-1-(4-phenyl-1H-imidazol-2-yl)ethyl]amino] methyl-2-methoxybenzoic acid and its polymorphs thereof | OPRD1, OPRK1, OPRM1 | ACE 1707/4885ITGB3 1726/4885ITGA2B 1050/4885 |
| US-10479769-B2 | Processes for the preparation of eluxadoline | CYP3A5, AVPR2, CYP3A4 | ACE 377/4885ITGB3 2980/4885ITGA2B 2492/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.