SCHEMBL105629

SCHEMBL105629

COc1cc(Cl)nc(OC)n1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.55
TDP1 Q9NUW8 1/20 0.55
SMN1; SMN2 Q16637 4/20 0.50
ALDH1A1 P00352 4/20 0.50
L3MBTL1 Q9Y468 1/20 0.44
NPC1 O15118 3/20 0.41
RAB9A P51151 3/20 0.41
TP53 P04637 1/20 0.41
NFKB1 P19838 1/20 0.41
NFKB2 Q00653 1/20 0.41
RELA Q04206 1/20 0.41
KDM4E B2RXH2 1/20 0.41
CYP3A4 P08684 2/20 0.41
HTR6 P50406 1/20 0.41
CYP1A2 P05177 3/20 0.40
KMT2A Q03164 1/20 0.39
CASP3 P42574 1/20 0.38
SENP8 Q96LD8 1/20 0.38
SENP7 Q9BQF6 1/20 0.38
SENP6 Q9GZR1 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29693683 1.00 LMNA (0.55) LMNATDP1SMN1; SMN2ALDH1A1L3MBTL1
SCHEMBL232399 0.85 MAPT (0.41) LMNATDP1SMN1; SMN2ALDH1A1CYP1A2
SCHEMBL439716 0.83 LMNA (0.59) LMNATDP1SMN1; SMN2ALDH1A1L3MBTL1
SCHEMBL2339978 0.79 ALDH1A1 (0.47) LMNATDP1SMN1; SMN2ALDH1A1L3MBTL1
SCHEMBL1415356 0.78 L3MBTL1 (0.59) LMNASMN1; SMN2ALDH1A1L3MBTL1CYP3A4
SCHEMBL10241852 0.77 PDE2A (0.52) LMNATDP1SMN1; SMN2ALDH1A1L3MBTL1
SCHEMBL784628 0.77 LMNA (0.42) LMNASMN1; SMN2ALDH1A1NPC1RAB9A
SCHEMBL30318701 0.77 PDE2A (0.52) LMNATDP1SMN1; SMN2ALDH1A1L3MBTL1
SCHEMBL27519654 0.77 SMN1; SMN2 (0.42) LMNATDP1SMN1; SMN2ALDH1A1L3MBTL1
SCHEMBL2633440 0.76 ALDH1A1 (0.44) LMNATDP1SMN1; SMN2ALDH1A1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 384 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117209435-B Method for preparing 2, 6-dimethoxy-4-aminopyrimidine through micro-channel 浙江海昇药业股份有限公司 2026-05-12 CN claimed
CN-117209435-A Method for preparing 2, 6-dimethoxy-4-aminopyrimidine through micro-channel 浙江海昇药业股份有限公司 2023-12-12 CN claimed
CN-116042288-A Grease composition, preparation method thereof and application of pyrimidine compound and fatty alcohol 中国石油化工股份有限公司 2023-05-02 CN claimed
US-6176909-B1 IN POLYMERIC BINDER XEROX CORPORATION 2001-01-23 US claimed
EP-0743574-B1 Migration imaging members XEROX CORP (US) 2000-12-27 EP claimed
EP-0743573-B1 Method for obtaining image contrast migration imaging members XEROX CORP (US) 2000-09-06 EP claimed
US-5939568-A Accelerated catalysis of olefinic epoxidations THE SCRIPPS RESEARCH INSTITUTE (US) 1999-08-17 US claimed
EP-0743574-A2 Migration imaging members XEROX CORPORATION (US) 1996-11-20 EP claimed
EP-0743573-A2 Method for obtaining image contrast migration imaging members XEROX CORPORATION (US) 1996-11-20 EP claimed
US-5563014-A SOFTENABLE LAYER CONTAINIG PHOTOSENSITIVE MARKING MATERIAL; TRANSPARENTIZING AGENT XEROX CORPORATION (US) 1996-10-08 US claimed
US-5514505-A SELECTIVE TRANSPARENTIZATION OF PHOTOSENSITIVE MIGRATION MARKING PARTICLES EMBEDDED NEAR THE SURFACE OF A SOFTENABLE LAYER SUPPORTED BY AN ELECTROCONDUCTIVE SUBSTRATE XEROX CORPORATION (US) 1996-05-07 US claimed
EP-0267675-A2 Modified conjugated diene polymer and process for production thereof JAPAN SYNTHETIC RUBBER CO., LTD. (JP) 1988-05-18 EP claimed
CN-117209435-B Method for preparing 2, 6-dimethoxy-4-aminopyrimidine through micro-channel 浙江海昇药业股份有限公司 2026-05-12 CN disclosed
CN-117209435-B Method for preparing 2, 6-dimethoxy-4-aminopyrimidine through micro-channel 浙江海昇药业股份有限公司 2026-05-12 CN disclosed
EP-3845546-B1 COMPLEXES JOHNSON MATTHEY PLC (GB) 2024-06-19 EP disclosed
EP-3842421-B1 COMPLEXES JOHNSON MATTHEY PLC (GB) 2024-06-12 EP disclosed
EP-0406920-A2 Modified conjugated diene polymer and process for production thereof JAPAN SYNTHETIC RUBBER CO., LTD. (JP) 1991-01-09 EP disclosed
US-4906706-A Modified conjugated diene polymer and process for production thereof JAPAN SYNTHETIC RUBBER CO., LTD. (JP) 1990-03-06 US disclosed
EP-0267675-A2 Modified conjugated diene polymer and process for production thereof JAPAN SYNTHETIC RUBBER CO., LTD. (JP) 1988-05-18 EP disclosed
US-4167567-A Antihypertensive 4-aminoquinolines THE UPJOHN COMPANY (US) 1979-09-11 US disclosed