SCHEMBL232399

SCHEMBL232399

COc1nc(Cl)cc(Cl)n1

nearest known ligand 0.41

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.41
MEN1 O00255 1/20 0.41
TSHR P16473 1/20 0.41
KMT2A Q03164 1/20 0.41
ATM Q13315 1/20 0.41
GAA P10253 2/20 0.39
CYP1A2 P05177 1/20 0.39
MAT2A P31153 1/20 0.38
LMNA P02545 2/20 0.38
TDP1 Q9NUW8 1/20 0.38
ALDH1A1 P00352 4/20 0.37
SMN1; SMN2 Q16637 3/20 0.37
HSP90AA1 P07900 5/20 0.36
HSP90AB1 P08238 5/20 0.36
NQO2 P16083 2/20 0.34
POLB P06746 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29693683 0.85 LMNA (0.55) KMT2ACYP1A2LMNATDP1ALDH1A1
SCHEMBL105629 0.85 LMNA (0.55) KMT2ACYP1A2LMNATDP1ALDH1A1
SCHEMBL784628 0.85 LMNA (0.42) MAPTMEN1TSHRKMT2AATM
SCHEMBL6118304 0.84 MAPT (0.39) MAPTMEN1TSHRKMT2AATM
SCHEMBL10846333 0.82 SMN1; SMN2 (0.36) MAPTMEN1TSHRKMT2AATM
Hydrochloric Acid SCHEMBL11420669 0.82 MAPT (0.38) MAPTMEN1TSHRKMT2AATM
SCHEMBL12570771 0.80 NOS3 (0.34) MAPTMEN1TSHRKMT2AATM
SCHEMBL26698986 0.80 MAPT (0.38) MAPTMEN1TSHRKMT2AATM
SCHEMBL798987 0.80 ALDH1A1 (0.39) MAPTMEN1TSHRKMT2AATM
SCHEMBL4648295 0.79 MAPT (0.41) MAPTMEN1TSHRKMT2AATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 165 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119100997-A Sulfadiol preparation method of octyl 重庆康乐制药有限公司 2024-12-10 CN claimed
EP-2170837-B1 PROCESS FOR PREPARING 2-(3-{6-[2-(2,4-DICHLOROPHENYL)-ETHYLAMINO]-2-METHOXYPYRIMIDIN-4-YL)-PHENYL)-2-METHYLPROPIONIC ACID SANOFI SA (FR) 2011-11-02 EP claimed
US-20100184979-A1 NEW PROCESS FOR PREPARING 2-(3--PHENYL)-2-METHYLPROPRIONIC ACID SANOFI-AVENTIS (FR) 2010-07-22 US claimed
EP-2170837-A2 PROCESS FOR PREPARING 2-(3-{6-[2-(2,4-DICHLOROPHENYL)-ETHYLAMINO]-2-METHOXYPYRIMIDIN-4-YL)-PHENYL)-2-METHYLPROPIONIC ACID Sanofi-Aventis (FR) 2010-04-07 EP claimed
WO-2009006086-A2 A NEW PROCESS FOR PREPARING 2-(3-{6-[2-(2,4-DICHLOROPHENYL)-ETHYLAMINO]-2-METHOXYPYRIMIDIN-4-YL}-PHENYL)- 2-METHYLPROPIONIC ACID SANOFI-AVENTIS (FR) 2009-01-08 WO claimed
US-20260138956-A1 NOVEL COMPOUNDS AND USES THEREOF RECURSION PHARMACEUTICALS INC (US) 2026-05-21 US disclosed
US-20250092042-A1 HETEROARYL SUBSTITUTED SPIROPIPERIDINYL DERIVATIVES AND PHARMACEUTICAL USES THEREOF NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, INC. 2025-03-20 US disclosed
US-12209094-B2 CCR2 receptor antagonists and uses thereof CENTREXION THERAPEUTICS CORPORATION (US) 2025-01-28 US disclosed
CN-119100997-A Sulfadiol preparation method of octyl 重庆康乐制药有限公司 2024-12-10 CN disclosed
CN-119100997-A Sulfadiol preparation method of octyl 重庆康乐制药有限公司 2024-12-10 CN disclosed
US-12157737-B2 Heteroaryl substituted spiropiperidinyl derivatives and pharmaceutical uses thereof NOVARTIS AG (CH) 2024-12-03 US disclosed
US-20240246995-A1 PYRIMIDINONE DERIVATIVE AND PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND USE Shanghai Simr Biotechnology Co., Ltd. (CN) 2024-07-25 US disclosed
US-6875830-B2 Chelating pyrimidines as ligands for single-site olefin polymerization catalysts EQUISTAR CHEMICALS, LP (US) 2005-04-05 US disclosed
EP-1231211-B1 THIAZOLIDINEDIONE DERIVATIVES AS ANTIDIABETIC AGENTS VITA INVEST SA (ES) 2003-05-28 EP disclosed
US-20030013823-A1 CHELATING PYRIMIDINES AS LIGANDS FOR SINGLE-SITE OLEFIN POLYMERIZATION CATALYSTS EQUISTAR CHEMICALS, LP 2003-01-16 US disclosed
US-20030008987-A1 Chelating pyrimidines as ligands for single-site olefin polymerization catalysts EQUISTAR CHEMICALS, L.P. 2003-01-09 US disclosed
WO-2002098931-A1 CHELATING PYRIMIDINES AS LIGANDS FOR SINGLE-SITE OLEFIN POLYMERIZATION CATALYSTS EQUISTAR CHEMICALS, LP (US) 2002-12-12 WO disclosed
US-6489414-B1 THE CATALYST SYSTEM COMPRISES AN OPTIONAL ACTIVATOR AND A COMPLEX THAT INCORPORATES A GROUP 3 TO 10 TRANSITION METAL AND AT LEAST ONE NEUTRAL OR ANIONIC CHELATING PYRIMIDINE LIGAND. THE LIGANDS ARE EASY TO MAKE, AND THEY ARE READILY EQUISTAR CHEMICALS, LP 2002-12-03 US disclosed
EP-1231211-A1 THIAZOLIDINEDIONE DERIVATIVES AS ANTIDIABETIC AGENTS VITA-INVEST, S.A. (ES) 2002-08-14 EP disclosed
WO-1993005011-A1 NOVEL IMMUNOSUPPRESSANTS SANDOZ LTD. (CH) 1993-03-18 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100184979-A1 NEW PROCESS FOR PREPARING 2-(3--PHENYL)-2-METHYLPROPRIONIC ACID DCPS, HPD, PAH MAPT 3305/4885MEN1 658/4885TSHR 3138/4885
US-20260138956-A1 NOVEL COMPOUNDS AND USES THEREOF SLC10A1, NR3C2, CYP2C8 MAPT 3402/4885MEN1 2549/4885TSHR 1393/4885
US-12157737-B2 Heteroaryl substituted spiropiperidinyl derivatives and pharmaceutical uses thereof REN, NR3C2, PKD1 MAPT 4450/4885MEN1 1544/4885TSHR 904/4885
US-20240246995-A1 PYRIMIDINONE DERIVATIVE AND PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND USE PLA2G1B, LYPLAL1, PLA2G12B MAPT 4463/4885MEN1 1759/4885TSHR 3502/4885
US-20250092042-A1 HETEROARYL SUBSTITUTED SPIROPIPERIDINYL DERIVATIVES AND PHARMACEUTICAL USES THEREOF REN, PKD1, PKD2 MAPT 4190/4885MEN1 1485/4885TSHR 608/4885
US-12209094-B2 CCR2 receptor antagonists and uses thereof CCR2, CCRL2, CCR1 MAPT 4485/4885MEN1 4873/4885TSHR 844/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.