Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.60 |
| ▸ | MAPT | P10636 | 6/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | CASP3 | P42574 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.60 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.60 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.60 |
| ▸ | IKBKB | O14920 | 1/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 4/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | HPGD | P15428 | 5/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | GLA | P06280 | 3/20 | 0.42 |
| ▸ | ATM | Q13315 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL31120455 | 0.98 | KDM4E (0.59) | KDM4EMAPTNPC1CASP3RAB9A | |
| SCHEMBL9529269 | 0.81 | TSHR (0.45) | KDM4EMAPTNPC1CASP3RAB9A | |
| SCHEMBL27547199 | 0.81 | MAPT (0.42) | KDM4EMAPTNPC1CASP3RAB9A | |
| SCHEMBL166726 | 0.79 | MAPT (0.54) | KDM4EMAPTNPC1CASP3RAB9A | |
| SCHEMBL26281532 | 0.79 | KMT2A (0.44) | KDM4EMAPTNPC1CASP3RAB9A | |
| SCHEMBL28175472 | 0.79 | MAPT (0.44) | KDM4EMAPTNPC1CASP3RAB9A | |
| SCHEMBL3239031 | 0.79 | KDM4E (0.54) | KDM4EMAPTNPC1CASP3RAB9A | |
| SCHEMBL24523710 | 0.78 | KDM4E (0.53) | KDM4EMAPTNPC1CASP3RAB9A | |
| SCHEMBL102283 | 0.78 | KDM4E (0.53) | KDM4EMAPTNPC1CASP3RAB9A | |
| SCHEMBL14419258 | 0.78 | GAA (0.44) | KDM4EMAPTNPC1CASP3RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12617772-B2 | Hydroxypyridine HSD17B13 inhibitors and uses thereof | INIPHARM, INC. (US) | 2026-05-05 | — | — | US | disclosed |
| US-20240208929-A1 | HYDROXYPYRIDINE HSD17B13 INHIBITORS AND USES THEREOF | INIPHARM, INC. | 2024-06-27 | — | — | US | disclosed |
| US-20240208929-A1 | HYDROXYPYRIDINE HSD17B13 INHIBITORS AND USES THEREOF | INIPHARM, INC. | 2024-06-27 | — | — | US | disclosed |
| US-20240208929-A1 | HYDROXYPYRIDINE HSD17B13 INHIBITORS AND USES THEREOF | INIPHARM, INC. | 2024-06-27 | — | — | US | disclosed |
| EP-4320111-A1 | HYDROXYPYRIDINE HSD17B13 INHIBITORS AND USES THEREOF | Inipharm, Inc. (US) | 2024-02-14 | — | — | EP | disclosed |
| CN-117024441-A | MAT2A inhibitor | 武汉人福创新药物研发中心有限公司 | 2023-11-10 | — | — | CN | disclosed |
| WO-2022216626-A1 | HYDROXYPYRIDINE HSD17B13 INHIBITORS AND USES THEREOF | INIPHARM, INC. (US) | 2022-10-13 | — | — | WO | disclosed |
| EP-3152207-B1 | PYRIDOPYRIMIDINEDIONE DERIVATIVES AS SUPPRESSORS OF NON-SENS MUTATIONS | NOVARTIS AG (CH) | 2019-05-08 | — | — | EP | disclosed |
| US-9884862-B2 | Pyridopyrimidinedione derivatives | NOVARTIS AG (CH) | 2018-02-06 | — | — | US | disclosed |
| US-20170197959-A1 | Pyridopyrimidinedione derivatives | NOVARTIS AG (CH) | 2017-07-13 | — | — | US | disclosed |
| EP-3152207-A1 | PYRIDOPYRIMIDINEDIONE DERIVATIVES | Novartis AG (CH) | 2017-04-12 | — | — | EP | disclosed |
| WO-2015186061-A1 | PYRIDOPYRIMIDINEDIONE DERIVATIVES | NOVARTIS AG (CH) | 2015-12-10 | — | — | WO | disclosed |
| US-20110237599-A1 | HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2011-09-29 | — | — | US | disclosed |
| US-4797486-A | ANTIPROTOZOA AGENTS | PFIZER INC. (US) | 1989-01-10 | — | — | US | disclosed |
| US-4725599-A | POULTRY | PFIZER INC. (US) | 1988-02-16 | — | — | US | disclosed |
| US-4710506-A | Antihypertensive thienopyridines | THE BOOTS COMPANY PLC (GB) | 1987-12-01 | — | — | US | disclosed |
| EP-0209977-A2 | Thienopyridones, processes and intermediates for their preparation and pharmaceutical compositions containing them | The Boots Company PLC (GB) | 1987-01-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110237599-A1 | HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE | HRH4, HRH3, HRH2 | KDM4E 1897/4885MAPT 2336/4885NPC1 2861/4885 |
| US-20170197959-A1 | Pyridopyrimidinedione derivatives | DPYD, TPMT, CYP2D6 | KDM4E 1677/4885MAPT 2347/4885NPC1 3468/4885 |
| US-20240208929-A1 | HYDROXYPYRIDINE HSD17B13 INHIBITORS AND USES THEREOF | HSD17B3, HSD17B1, HSD17B13 | KDM4E 2653/4885MAPT 3557/4885NPC1 496/4885 |
| US-12617772-B2 | Hydroxypyridine HSD17B13 inhibitors and uses thereof | HSD11B1, HSD17B1, HSD3B1 | KDM4E 4079/4885MAPT 4587/4885NPC1 98/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.