Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL10567218 | 1.00 | ALDH1A1 (0.48) | ALDH1A1HTTDRD2DRD4DRD3 | |
| SCHEMBL10565925 | 0.98 | DRD2 (0.49) | ALDH1A1HTTDRD2DRD4DRD3 | |
| Oxalic Acid SCHEMBL10566726 | 0.93 | DRD2 (0.49) | ALDH1A1HTTDRD2DRD4DRD3 | |
| Oxalic Acid SCHEMBL10566732 | 0.93 | DRD2 (0.49) | ALDH1A1HTTDRD2DRD4DRD3 | |
| SCHEMBL10566765 | 0.91 | DRD2 (0.51) | ALDH1A1HTTDRD2DRD4DRD3 | |
| SCHEMBL10566772 | 0.91 | DRD2 (0.51) | ALDH1A1HTTDRD2DRD4DRD3 | |
| Oxalic Acid SCHEMBL10564624 | 0.90 | ATM (0.45) | ALDH1A1HTTKDM4EKMT2AMEN1 | |
| Oxalic Acid SCHEMBL10564631 | 0.90 | ATM (0.45) | ALDH1A1HTTKDM4EKMT2AMEN1 | |
| SCHEMBL10567624 | 0.88 | ADRB2 (0.43) | ALDH1A1KMT2AMAPTMEN1CYP2D6 | |
| SCHEMBL10566298 | 0.88 | ADRB2 (0.43) | ALDH1A1KMT2AMAPTMEN1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4843085-A | LOCAL ANESTHETICS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1989-06-27 | — | — | US | disclosed |
| EP-0297613-A2 | Pyridine derivatives, process for production thereof and pharmaceutical composition containing them | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1989-01-04 | — | — | EP | disclosed |