Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.44 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | GGT1 | P19440 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10567455 | 0.85 | SMN1; SMN2 (0.54) | ALDH1A1KDM4EHPGDHSD17B10ALOX15 | |
| SCHEMBL11541423 | 0.82 | MAPT (0.59) | ALDH1A1KDM4EHPGDHSD17B10ESR1 | |
| SCHEMBL10801573 | 0.82 | L3MBTL1 (0.46) | ALDH1A1TSHRALOX15KMT2AMAPT | |
| SCHEMBL11541467 | 0.81 | CNR2 (0.52) | ALDH1A1KDM4EHPGDHSD17B10ESR1 | |
| SCHEMBL11541053 | 0.79 | MAPT (0.42) | ALDH1A1KDM4EHPGDHSD17B10ESR1 | |
| SCHEMBL10664238 | 0.78 | CYP2C9 (0.60) | ALDH1A1KDM4EHPGDHSD17B10TSHR | |
| SCHEMBL11541127 | 0.77 | ALDH1A1 (0.47) | ALDH1A1HPGDESR1TSHRKMT2A | |
| SCHEMBL11540900 | 0.76 | MAPT (0.52) | ALDH1A1KDM4EHPGDHSD17B10TSHR | |
| SCHEMBL10656996 | 0.75 | ALDH1A1 (0.48) | ALDH1A1KDM4EHPGDHSD17B10TSHR | |
| SCHEMBL6692079 | 0.75 | CFD (0.56) | ALDH1A1KDM4EHPGDHSD17B10ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4166819-A | HYPOTENSIVES, DIURETICS | ABBOTT LABORATORIES (US) | 1979-09-04 | — | — | US | disclosed |
| US-4058559-A | HYPOTENSIVE AGENTS, DIURETICS, URICOSURIC AGENTS | ABBOTT LABORATORIES (US) | 1977-11-15 | — | — | US | disclosed |