Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | LOX | P28300 | 1/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.38 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NNMT | P40261 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29907787 | 1.00 | MPO (0.44) | MPOKDM1AMAOAMAOBLOX | |
| Hydrochloric Acid SCHEMBL10567170 | 0.98 | MPO (0.43) | MPOKDM1AMAOAMAOBLOX | |
| SCHEMBL2940008 | 0.84 | MPO (0.43) | MPOKDM1AMAOAMAOBADORA2A | |
| SCHEMBL29792045 | 0.84 | MPO (0.43) | MPOKDM1AMAOAMAOBADORA2A | |
| Hydrochloric Acid SCHEMBL28899248 | 0.82 | MPO (0.42) | MPOKDM1AMAOAMAOBADORA2A | |
| SCHEMBL217520 | 0.81 | KDM1A (0.45) | MPOKDM1AMAOAMAOBADORA2A | |
| SCHEMBL18266390 | 0.80 | MAPK8 (0.46) | BTKGRM5KCNH2ALDH1A1 | |
| SCHEMBL4377728 | 0.80 | MPO (0.43) | MPOKDM1AMAOAMAOBADORA2A | |
| SCHEMBL18705 | 0.79 | KDM1A (0.44) | MPOKDM1AMAOAMAOBADORA2A | |
| SCHEMBL128108 | 0.79 | KDM1A (0.44) | MPOKDM1AMAOAMAOBADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2681215-B1 | SERINE/THREONINE KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2015-04-22 | — | — | EP | claimed |
| US-12534463-B2 | Substituted tricyclic compounds as FGFR inhibitors | INCYTE CORPORATION (US) | 2026-01-27 | — | — | US | disclosed |
| US-20250289792-A1 | 3-AMINO-4H-BENZO[E][1,2,4]THIADIAZINE 1,1-DIOXIDE DERIVATIVES AS INHIBITORS OF MRGX2 | SOLENT THERAPEUTICS LLC (US) | 2025-09-18 | — | — | US | disclosed |
| US-12247015-B2 | 3-amino-4H-benzo[e][1,2,4]thiadiazine 1,1-dioxide derivatives as inhibitors of MRGX2 | SOLENT THERAPEUTICS, LLC (US) | 2025-03-11 | — | — | US | disclosed |
| US-20240246974-A1 | SUBSTITUTED TRICYCLIC COMPOUNDS AS FGFR INHIBITORS | INCYTE CORPORATION | 2024-07-25 | — | — | US | disclosed |
| EP-4403216-A2 | SUBSTITUTED TRICYCLIC COMPOUNDS AS FGFR INHIBITORS | Incyte Holdings Corporation (US) | 2024-07-24 | — | — | EP | disclosed |
| CN-115181092-B | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2024-05-03 | — | — | CN | disclosed |
| EP-3822273-B1 | SUBSTITUTED TRICYCLIC COMPOUNDS AS FGFR INHIBITORS | INCYTE HOLDINGS CORP (US) | 2024-04-10 | — | — | EP | disclosed |
| WO-2024067304-A1 | COMPOUND WITH INHIBITORY ACTIVITY AGAINST SIGMA2 AND 5HT2A AND USE | 瀚远医药有限公司 | 2024-04-04 | — | — | WO | disclosed |
| US-20240067631-A1 | PYRAZOLE DERIVATIVES USEFUL AS NAMPT MODULATORS | CYTOKINETICS, INC. | 2024-02-29 | — | — | US | disclosed |
| EP-2861595-A2 | SUBSTITUTED TRICYCLIC COMPOUNDS AS FGFR INHIBITORS | Incyte Corporation (US) | 2015-04-22 | — | — | EP | disclosed |
| WO-2014007951-A2 | SUBSTITUTED TRICYCLIC COMPOUNDS AS FGFR INHIBITORS | INCYTE CORPORATION (US) | 2014-01-09 | — | — | WO | disclosed |
| US-20130338134-A1 | SUBSTITUTED TRICYCLIC COMPOUNDS AS FGFR INHIBITORS | INCYTE CORPORATION | 2013-12-19 | — | — | US | disclosed |
| US-7803947-B2 | Method for producing thiocarbamate derivative | ZENYAKU KOGYO KABUSHIKIKAISHA (JP) | 2010-09-28 | — | — | US | disclosed |
| CN-101801972-A | Pyrazolo [1,5-A]pyrimidines as inhibitors of stearoyl-coA desaturase | INOVACIA AB | 2010-08-11 | — | — | CN | disclosed |
| US-20090247762-A1 | METHOD FOR PRODUCING THIOCARBAMATE DERIVATIVE | ZENYAKU KOGYO KABUSHIKIKAISHA (JP) | 2009-10-01 | — | — | US | disclosed |
| US-4824953-A | Multi-step process for producing 5-hydroxy-N-(6-oxo-piperidyl-methyl)-2-(2,2,2-trifluoro-ethoxy)-benzamide and derivatives | RIKER LABORATORIES, INC. (US) | 1989-04-25 | — | — | US | disclosed |
| US-4656285-A | Compound 2-acetamidomethyl-6-methoxy-pyridine | RIKER LABORATORIES, INC. (US) | 1987-04-07 | — | — | US | disclosed |
| US-4555573-A | Certain 6-benzamidomethyl-2(1H)-pyridone derivatives | RIKER LABORATORIES, INC. (US) | 1985-11-26 | — | — | US | disclosed |
| US-4496734-A | Metabolite | RIKER LABORATORIES, INC. (US) | 1985-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12247015-B2 | 3-amino-4H-benzo[e][1,2,4]thiadiazine 1,1-dioxide derivatives as inhibitors of MRGX2 | TPX2, MRGPRX2, CBX2 | MPO 4220/4885KDM1A 998/4885MAOA 1474/4885 |
| US-12534463-B2 | Substituted tricyclic compounds as FGFR inhibitors | FGFR3, FGFR1, FGFR4 | MPO 4881/4885KDM1A 1336/4885MAOA 3400/4885 |
| US-20250289792-A1 | 3-AMINO-4H-BENZO[E][1,2,4]THIADIAZINE 1,1-DIOXIDE DERIVATIVES AS INHIBITORS OF MRGX2 | TPX2, CBX2, RIOX2 | MPO 4324/4885KDM1A 1064/4885MAOA 1762/4885 |
| US-20240246974-A1 | SUBSTITUTED TRICYCLIC COMPOUNDS AS FGFR INHIBITORS | FGFR3, FGFR1, FGFR2 | MPO 4862/4885KDM1A 589/4885MAOA 3739/4885 |
| US-20130338134-A1 | SUBSTITUTED TRICYCLIC COMPOUNDS AS FGFR INHIBITORS | FGFR3, FGFR1, FGFR2 | MPO 4862/4885KDM1A 589/4885MAOA 3739/4885 |
| US-20240067631-A1 | PYRAZOLE DERIVATIVES USEFUL AS NAMPT MODULATORS | NAMPT, NNT, NAPRT | MPO 1605/4885KDM1A 2981/4885MAOA 981/4885 |
| US-20090247762-A1 | METHOD FOR PRODUCING THIOCARBAMATE DERIVATIVE | TXN, TXN2, NAT1 | MPO 1045/4885KDM1A 1156/4885MAOA 1218/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.