SCHEMBL18705

SCHEMBL18705

COc1cccc(CBr)n1

nearest known ligand 0.44

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
KDM1A O60341 1/20 0.44
MAOA P21397 1/20 0.44
MAOB P27338 1/20 0.44
MPO P05164 1/20 0.41
CCR1 P32246 1/20 0.40
HTR7 P34969 1/20 0.40
BTK Q06187 1/20 0.38
ADORA2A P29274 1/20 0.36
LIPG Q9Y5X9 1/20 0.36
GRM5 P41594 1/20 0.36
KCNH2 Q12809 1/20 0.35
KDM4E B2RXH2 2/20 0.34
ALDH1A1 P00352 1/20 0.34
HPGD P15428 1/20 0.34
ALOX5 P09917 1/20 0.34
TAAR1 Q96RJ0 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29427090 1.00 KDM1A (0.44) KDM1AMAOAMAOBMPOCCR1
Formic Acid Methyl Ester SCHEMBL31051630 0.89 KDM1A (0.39) KDM1AMAOAMAOBMPOCCR1
SCHEMBL217520 0.81 KDM1A (0.45) KDM1AMAOAMAOBMPOBTK
SCHEMBL29525054 0.79 KDM1A (0.44) KDM1AMAOAMAOBMPOBTK
SCHEMBL10568321 0.79 MPO (0.44) KDM1AMAOAMAOBMPOBTK
SCHEMBL29907787 0.79 MPO (0.44) KDM1AMAOAMAOBMPOBTK
SCHEMBL9991287 0.79 KDM1A (0.44) KDM1AMAOAMAOBMPOBTK
SCHEMBL128108 0.79 KDM1A (0.44) KDM1AMAOAMAOBMPOBTK
SCHEMBL509881 0.79 KDM1A (0.44) KDM1AMAOAMAOBMPOBTK
SCHEMBL8477471 0.79 KDM1A (0.44) KDM1AMAOAMAOBMPOBTK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 122 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118271239-B Synthesis method of 3- (6-methoxy-2-pyridine) -propionic acid 聊城大学 2025-02-11 CN claimed
CN-118271239-A Synthesis method of 3- (6-methoxy-2-pyridine) -propionic acid 聊城大学 2024-07-02 CN claimed
CN-111825619-A Benzimidazole derivative and application thereof 济南大学 2020-10-27 CN claimed
US-20260098060-A1 MACROCYCLIC CFTR MODULATORS IDORSIA PHARMACEUTICALS LTD (CH) 2026-04-09 US disclosed
EP-4587443-A1 MACROCYCLIC CFTR MODULATORS Idorsia Pharmaceuticals Ltd (CH) 2025-07-23 EP disclosed
WO-2025076285-A1 COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME DELPHIA THERAPEUTICS, INC. (US) 2025-04-10 WO disclosed
EP-4217062-B1 CYCLOBUTYL AMIDE MONOACYLGLYCEROL LIPASE MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2024-10-09 EP disclosed
CN-118271239-A Synthesis method of 3- (6-methoxy-2-pyridine) -propionic acid 聊城大学 2024-07-02 CN disclosed
CN-118271239-A Synthesis method of 3- (6-methoxy-2-pyridine) -propionic acid 聊城大学 2024-07-02 CN disclosed
US-20240208902-A1 CYCLOBUTYL AMIDE MONOACYLGLYCEROL LIPASE MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2024-06-27 US disclosed
US-20240174685-A1 OX2R Compounds BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2024-05-30 US disclosed
US-5852016-A Quinoxaline derivatives useful in therapy PFIZER INC. (US) 1998-12-22 US disclosed
CN-1158610-A Quinoxaline derivatives useful in therapy PFIZER LTD (IE) 1997-09-03 CN disclosed
EP-0783495-A1 QUINOXALINE DERIVATIVES USEFUL IN THERAPY Pfizer Limited (GB) 1997-07-16 EP disclosed
WO-1996009295-A1 QUINOXALINE DERIVATIVES USEFUL IN THERAPY PFIZER LIMITED (GB) 1996-03-28 WO disclosed
US-4426526-A HISTAMINE ANTAGONISTS, ANTIINFLAMMATORY, ANTISECRETORY SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1984-01-17 US disclosed
US-4264608-A HISTAMINE ANTAGONISTS SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1981-04-28 US disclosed
US-4215126-A HISTAMINE H2 BLOCKING SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1980-07-29 US disclosed
US-4156727-A ANTIHISTAMINES SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1979-05-29 US disclosed
US-4154838-A ANTIHISTAMINE SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1979-05-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260098060-A1 MACROCYCLIC CFTR MODULATORS CFTR, CLIC1, ARRB1 KDM1A 4207/4885MAOA 2403/4885MAOB 3350/4885
US-20240174685-A1 OX2R Compounds HCRTR2, HCRTR1, OXTR KDM1A 2826/4885MAOA 1873/4885MAOB 1233/4885
US-20240208902-A1 CYCLOBUTYL AMIDE MONOACYLGLYCEROL LIPASE MODULATORS MGLL, LPL, PNLIP KDM1A 2647/4885MAOA 118/4885MAOB 99/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.