Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.58 |
| ▸ | DRD2 | P14416 | 4/20 | 0.56 |
| ▸ | DRD3 | P35462 | 4/20 | 0.56 |
| ▸ | DRD4 | P21917 | 3/20 | 0.56 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.56 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.56 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.56 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.56 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.56 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.56 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.56 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.52 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.52 |
| ▸ | HTR7 | P34969 | 3/20 | 0.52 |
| ▸ | HTR1A | P08908 | 2/20 | 0.52 |
| ▸ | DRD5 | P21918 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10568199 | 0.89 | SIGMAR1 (0.58) | SIGMAR1DRD2DRD3DRD4ADRB2 | |
| SCHEMBL10575317 | 0.84 | SIGMAR1 (0.54) | SIGMAR1DRD2DRD3DRD4ADRB2 | |
| SCHEMBL10567416 | 0.84 | SIGMAR1 (0.54) | SIGMAR1DRD2DRD3DRD4ADRB2 | |
| SCHEMBL11065111 | 0.84 | SIGMAR1 (0.53) | SIGMAR1DRD2DRD3DRD4CHRM2 | |
| SCHEMBL10570155 | 0.83 | HTR1A (0.57) | SIGMAR1DRD2DRD3DRD4ADRB2 | |
| SCHEMBL9364940 | 0.82 | SIGMAR1 (0.81) | SIGMAR1DRD2DRD3DRD4ADRB2 | |
| SCHEMBL10569588 | 0.82 | SIGMAR1 (0.56) | SIGMAR1DRD2DRD3DRD4HTR7 | |
| Hydrochloric Acid SCHEMBL9085153 | 0.81 | SIGMAR1 (0.80) | SIGMAR1DRD2DRD3DRD4ADRB2 | |
| SCHEMBL10572966 | 0.79 | DRD2 (0.52) | SIGMAR1DRD2DRD3DRD4ADRA1D | |
| SCHEMBL10572717 | 0.78 | HTR1A (0.53) | SIGMAR1DRD2DRD3DRD4ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4824840-A | ANTIHISTAMINES, NERVOUS SYSTEM CONTROLLERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1989-04-25 | — | — | US | disclosed |
| US-4734416-A | ANTIHISTAMINES, CENTRAL NERVOUS SYSTEM CONTROLLING ACTION | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1988-03-29 | — | — | US | disclosed |