Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 4/20 | 0.50 |
| ▸ | DRD2 | P14416 | 8/20 | 0.48 |
| ▸ | HTR2A | P28223 | 4/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | HRH2 | P25021 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 4/20 | 0.46 |
| ▸ | DRD4 | P21917 | 2/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10570006 | 0.84 | KCNA5 (0.50) | KCNA5DRD2HTR2ASIGMAR1HRH2 | |
| Hydrochloric Acid SCHEMBL10570958 | 0.83 | KCNA5 (0.49) | KCNA5DRD2HTR2ASIGMAR1HRH2 | |
| SCHEMBL11066899 | 0.81 | HTR7 (0.50) | DRD2HTR2ASIGMAR1HRH1DRD3 | |
| SCHEMBL11071804 | 0.80 | HTR7 (0.53) | DRD2DRD3DRD4 | |
| SCHEMBL10572638 | 0.80 | DRD2 (0.63) | DRD2HTR2ADRD3DRD4MAOA | |
| SCHEMBL11064023 | 0.80 | DRD2 (0.51) | DRD2SIGMAR1DRD3DRD4MAOA | |
| SCHEMBL10570804 | 0.79 | DRD2 (0.73) | DRD2HTR2ADRD3DRD4MAOA | |
| SCHEMBL11063139 | 0.79 | DRD3 (0.47) | DRD2DRD3DRD4 | |
| SCHEMBL11071104 | 0.78 | MAOA (0.61) | DRD2SIGMAR1DRD3DRD4MAOA | |
| SCHEMBL10570573 | 0.78 | DRD2 (0.69) | DRD2HTR2ADRD3DRD4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4824840-A | ANTIHISTAMINES, NERVOUS SYSTEM CONTROLLERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1989-04-25 | — | — | US | disclosed |
| US-4734416-A | ANTIHISTAMINES, CENTRAL NERVOUS SYSTEM CONTROLLING ACTION | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1988-03-29 | — | — | US | disclosed |