Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TCF4 | P15884 | 1/20 | 0.53 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.53 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.49 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 2/20 | 0.46 |
| ▸ | NPBWR1 | P48145 | 4/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.43 |
| ▸ | SCD | O00767 | 1/20 | 0.43 |
| ▸ | DGAT1 | O75907 | 5/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.42 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10573285 | 0.92 | TCF4 (0.45) | TCF4CTNNB1SIRT2SIRT1AURKA | |
| SCHEMBL10574680 | 0.88 | NPBWR1 (0.59) | NPBWR1HDAC6TRPV1SCDDGAT1 | |
| SCHEMBL10578004 | 0.87 | NPBWR1 (0.58) | NPBWR1TRPV1DGAT1KCNH2SOAT1 | |
| SCHEMBL10577338 | 0.87 | DGAT1 (0.57) | NPBWR1HDAC6TRPV1SCDDGAT1 | |
| SCHEMBL10578710 | 0.87 | MEN1 (0.49) | SIRT2SIRT1NPBWR1HDAC6TRPV1 | |
| SCHEMBL10578455 | 0.87 | NPBWR1 (0.56) | NPBWR1HDAC6TRPV1SCDDGAT1 | |
| SCHEMBL10574710 | 0.86 | NPC1 (0.51) | NPBWR1HDAC6TRPV1SCDDGAT1 | |
| SCHEMBL10574279 | 0.85 | SLC2A1 (0.55) | NPBWR1TRPV1TP53MAPTSMN1; SMN2 | |
| SCHEMBL10576865 | 0.83 | HDAC6 (0.43) | NPBWR1HDAC6TRPV1SCDDGAT1 | |
| SCHEMBL10571906 | 0.83 | DGAT1 (0.42) | NPBWR1HDAC6TRPV1SCDDGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4882342-A | CARDIOVASCULAR DISORDERS | BOEHRINGER MANNHEIM GMBH (DE) | 1989-11-21 | — | — | US | disclosed |
| EP-0266558-A2 | 5-Alkylbenzimidazoles, process for their preparation and medicaments containing them | Roche Diagnostics GmbH (DE) | 1988-05-11 | — | — | EP | disclosed |