Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TCF4 | P15884 | 1/20 | 0.45 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 7/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | GUSB | P08236 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
| ▸ | FASN | P49327 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10573294 | 0.92 | TCF4 (0.53) | TCF4CTNNB1AURKASIRT2SIRT1 | |
| SCHEMBL10580688 | 0.89 | HDAC6 (0.52) | HDAC6MAPTNPBWR1PARP1TRPV1 | |
| SCHEMBL10574665 | 0.88 | NPBWR1 (0.47) | HDAC6KDM4ENPC1MAPTRAB9A | |
| SCHEMBL10577324 | 0.87 | DGAT1 (0.46) | HDAC6GUSBMAPTNPBWR1TRPV1 | |
| SCHEMBL10578691 | 0.87 | GUSB (0.43) | SIRT2SIRT1HDAC6KDM4ENPC1 | |
| SCHEMBL10577985 | 0.87 | NPBWR1 (0.46) | HDAC6RAB9ANPBWR1TRPV1 | |
| SCHEMBL10578441 | 0.87 | HDAC6 (0.46) | HDAC6KDM4ENPC1MAPTRAB9A | |
| SCHEMBL10574691 | 0.86 | KDM4E (0.43) | HDAC6KDM4ENPC1GUSBMAPT | |
| SCHEMBL10574269 | 0.85 | NPC1 (0.48) | HDAC6KDM4ENPC1GUSBMAPT | |
| SCHEMBL10571887 | 0.83 | KIT (0.39) | HDAC6KDM4ENPC1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4882342-A | CARDIOVASCULAR DISORDERS | BOEHRINGER MANNHEIM GMBH (DE) | 1989-11-21 | — | — | US | disclosed |
| EP-0266558-A2 | 5-Alkylbenzimidazoles, process for their preparation and medicaments containing them | Roche Diagnostics GmbH (DE) | 1988-05-11 | — | — | EP | disclosed |