Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 6/20 | 0.40 |
| ▸ | RAB9A | P51151 | 5/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | NPBWR1 | P48145 | 4/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | TNKS | O95271 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10575692 | 0.91 | NPBWR1 (0.49) | HDAC6NPC1NPBWR1KDM4EALDH1A1 | |
| SCHEMBL10579325 | 0.85 | DGAT1 (0.51) | HDAC6NPBWR1ALDH1A1DGAT1KCNH2 | |
| SCHEMBL10574912 | 0.83 | MITF (0.37) | HDAC6NPC1RAB9APKMNPBWR1 | |
| SCHEMBL10577465 | 0.82 | NPBWR1 (0.53) | HDAC6NPC1RAB9APKMNPBWR1 | |
| SCHEMBL10576078 | 0.80 | HDAC6 (0.52) | HDAC6NPC1RAB9ANPBWR1KDM4E | |
| SCHEMBL10578011 | 0.80 | MAPT (0.55) | HDAC6NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL10573939 | 0.79 | KDM4E (0.49) | HDAC6NPC1RAB9ANPBWR1KDM4E | |
| SCHEMBL10573902 | 0.79 | NPC1 (0.54) | HDAC6NPC1RAB9APKMNPBWR1 | |
| SCHEMBL15245185 | 0.77 | DGAT1 (0.63) | NPBWR1DGAT1KCNH2SOAT1 | |
| SCHEMBL10579198 | 0.77 | ALOX5 (0.53) | HDAC6KDM4EALDH1A1PARP1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4882342-A | CARDIOVASCULAR DISORDERS | BOEHRINGER MANNHEIM GMBH (DE) | 1989-11-21 | — | — | US | disclosed |
| EP-0266558-A2 | 5-Alkylbenzimidazoles, process for their preparation and medicaments containing them | Roche Diagnostics GmbH (DE) | 1988-05-11 | — | — | EP | disclosed |